Developmental Biology and Musculoskeletal Tissue Engineering (eBook, ePUB)

Principles and Applications
Redaktion: Stoddart, Martin J.; Gardner, Oliver F. W.; Pattappa, Girish; Craft, April M.

• Format: ePub

Produktbeschreibung

Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies.

Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells.

• Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes
• Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues
• Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering
• Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering
• Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 270
• Erscheinungstermin: 24. April 2018
• Englisch
• ISBN-13: 9780128115381
• Artikelnr.: 50521715

Autorenporträt

Dr. April Craft is an Assistant Professor of Orthopaedic Surgery & Research at Boston Children's Hospital and Harvard Medical School, and Principal Faculty at the Harvard Stem Cell Institute. Her research focuses on both developmental biology and translational medicine, and involves the use of pluripotent stem cells to understand how articular chondrocytes and cartilage tissues are specified during embryonic development and to generate appropriate cells and tissues for repair.

April Craft received her Bachelor of Science cum laude from Westminster College (New Wilmington, PA) and her Ph.D. from the University of Pittsburgh School of Medicine (Pittsburgh, PA). She completed her doctoral thesis in the gene therapy-based laboratory of Dr. Joseph Glorioso where she engineered non-toxic viral vectors suitable for gene expression in stem cells, and developed viral replication-based functional genomics platforms to screen for genes that activate developmental programs. During h

er post-doctoral studies in Dr. Gordon Keller's laboratory at the McEwen Centre for Regenerative Medicine (Toronto, Canada), she developed methods to reliably and reproducibly generate both articular and growth plate-like cartilage from mouse and human pluripotent stem cells. She accomplished this by recapitulating the developmental events that contribute to the specification of these tissues in utero, an approach that resulted in cartilaginous cells and tissues that are both molecularly and functionally distinct. Dr. Craft is currently an Assistant Professor at Boston Children's Hospital and Harvard Medical School, where her laboratory continues to study the development of cartilage and other synovial joint tissues with hopes of applying this knowledge toward the development of therapeutics for disease attenuation and tissue regeneration and repair.

Inhaltsangabe

1. Developmental biology of musculoskeletal tissues for Tissue Engineers
2. The Mechanics of Musculoskeletal Development
3. Developmental and orthopaedic diseases
4. Synovial joint development
5. Articular and Growth plate Cartilage development
6. Bone development
7. Disc development
8. Tendon development
9. Biomimetic tissue engineering based on human development
10. Clinical translation