Developmental Endocrinology (eBook, PDF)

From Research to Clinical Practice
Redaktion: Eugster, Erica A.; Pescovitz, Ora Hirsch

• Format: PDF

Produktbeschreibung

Recent advances in molecular endocrinology have significantly increased our understanding of endocrine diseases, as well as that of the medical management of these complicated disorders. In Developmental Endocrinology: From Research to Clinical Practice, leading researchers comprehensively translate all the latest scientific information regarding endocrine physiology and development into an understanding of the clinical pathogenesis, diagnosis, and treatment of these diseases. Organized by endocrine system, each section of the book concisely describes the chronological development of the human organism, from the fetal/prenatal period through childhood, adolescence, and, in some cases, into adulthood. The prenatal sections review recent discoveries concerning transcription factors, homeobox genes, and human molecular mutations- the basic processes governing prenatal development of the individual endocrine organs--and detail the pathophysiology, clinical characteristics, and treatment of pediatric endocrine disorders. Authoritative, comprehensive, and readily accessible, Developmental Endocrinology: From Research to Clinical Practice illuminates for today's medical investigators, basic scientists, and clinicians our rapidly emerging understanding of this complex field, as well as constituting an invaluable guide to the practical clinical management of endocrine diseases.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 421
• Erscheinungstermin: 4. März 2002
• Englisch
• ISBN-13: 9781592591565
• Artikelnr.: 44045574

Inhaltsangabe

I Hypothalamus/Pituitary.- 1 Transcriptional Control of the Development and Function of the Hypothalamic-Pituitary Axis.- II Growth.- 2 Molecular Mutations in the Human Growth Hormone Axis.- 3 Normal and Abnormal Growth.- 4 Adult Growth Hormone Deficiency.- III Thyroid.- 5 Molecular Mechanisms of Thyroid Gland Development: Insights from Clinical Studies and from Mutant Mice.- 6 Fetal-Perinatal Thyroid Physiology.- 7 Thyroid Disorders in Children and Adolescents.- IV Calcium and Bone.- 8 Genetic Control of Parathyroid Gland Development and Molecular Insights into Hypoparathyroidism.- 9 Bone Physiology.- 10 Pediatric Bone Disease.- V Gonadal Development.- 11 Transcriptional Development of the Hypothalamic-Pituitary-Gonadal Axis.- 12 Sexual Differentiation.- 13 Prenatal Androgens and Sexual Differentiation of Behavior.- 14 Normal and Precocious Puberty.- 15 Delayed Puberty.- VI Adrenal.- 16 Molecular Development of the Hypothalamic-Pituitary-Adrenal (HPA) Axis.- 17 Molecular Genetics of Adrenal Disease.

Rezensionen

"The coverage of calcium and bone is outstanding, being detailed, highly informative, wide-ranging - and dense! I was also highly impressed by the chapter on sexual differentiation, which is a model of clarity, well diagrammed and both informative and authoritative on clinical topics such as sex assignment. The chapter on precocious puberty is valuable for the clinician, as is the one on delayed puberty, which covers molecular and developmental aspects as well as clinical management. The final section of hypothalamic pituitary-adrenal development and genetic defects in steroidogenesis really is the icing on the cake, and completes what is a very impressive volume. the book is, above all, a valuable source of information for the reader, both scientist and clinician, who has specific questions to answer. Overall, is succeeds in fulfilling the editors' stated aims" -The Endocrinologist

"The book presents an intensive evaluation of the genetic and molecular bases of developmental aspects of several endocrine systems, and the relationship of the new data to clinical medicine. The contributors are leaders in the field and each chapter is extensive and well documented. Developmental Endocrinology is packed with information, well referenced and well integrated with established concepts that form the physiological basis of endocrinology." - TRENDS in Endocrinology and Metabolism

"Highly recommended to endocrinologists, neonatalogists and geneticists." -Eugster