Chang-Hui Shen

Diagnostic Molecular Biology (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Diagnostic Molecular Biology, Second Edition describes the fundamentals of molecular biology in a clear, concise manner with each technique explained within its conceptual framework and current applications of clinical laboratory techniques comprehensively covered. This targeted approach covers the principles of molecular biology, including basic knowledge of nucleic acids, proteins and chromosomes; the basic techniques and instrumentations commonly used in the field of molecular biology, including detailed procedures and explanations; and the applications of the principles and techniques currently employed in the clinical laboratory. Topics such as whole exome sequencing, whole genome sequencing, RNA-seq, and ChIP-seq round out the discussion.

Fully updated, this new edition adds recent advances in the detection of respiratory virus infections in humans, like influenza, RSV, hAdV, hRV but also corona. This book expands the discussion on NGS application and its role in future precision medicine.

• Provides explanations on how techniques are used to diagnosis at the molecular level
• Explains how to use information technology to communicate and assess results in the lab
• Enhances our understanding of fundamental molecular biology and places techniques in context
• Places protocols into context with practical applications
• Includes extra chapters on respiratory viruses (Corona)

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 588
• Erscheinungstermin: 29. Juni 2023
• Englisch
• ISBN-13: 9780323986090
• Artikelnr.: 68345390

Autorenporträt

Chang-Hui Shen, PhD, is a Professor of Biology at the College of Staten Island, City University of New York, New York. Dr. Shen graduated from the National Chung-Hsing University, Taiwan, with both a BS and MS, earning his PhD from the University of Edinburgh, UK. He previously was a visiting fellow of the National Institutes of Health before taking a position at the College of Staten Island, City University of New York.

Dr. Shen's research focuses on understanding the mechanism of gene expression, with an emphasis on the roles of transcriptional coactivators in gene activation. He also pursues such topics as the regulation of programmed cell death through major cellular signal transduction pathways and transcriptional networks in the cell, as well as epigenetic regulation of neurodegenerative diseases. Dr. Shen has been teaching Diagnostic Molecular Biology for more than 15 years.

Inhaltsangabe

1. Nucleic Acids: DNA and RNA 2. Nucleic Acid-Based Cellular Activities -
DNA Replication, Damage, and Repair 3. Gene Expression: Transcription of
the Genetic Code 4. Gene Expression: Translation of the Genetic Code 5. The
Genome 6. Extraction and Purification of Nucleic Acids 7. Quantification
and Analysis of Nucleic Acids 8. Extraction and Purification of Proteins 9.
Quantification and Analysis of Proteins 10. Amplification of Nucleic Acids
11. Characterization of Nucleic Acids and Proteins 12. Techniques in
Sequencing 13. Genome and Transriptome Analysis 14. Molecular Diagnosis of
Chromosomal Disorders 15. Molecular Diagnosis of Gene Mutation and
Inherited Diseases 16. Molecular Diagnosis of Infectious Diseases 17. The
Biology of SARS-CoV-2 and the Molecular Diagnosis of COVID-19 18. Guidance
for Molecular Diagnostic Laboratory