DNA Damage, DNA Repair and Disease (eBook, PDF)

Volume 2
Redaktion: Dizdaroglu, Miral; Lloyd, R Stephen

• Format: PDF

Produktbeschreibung

The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, D ausgeliefert werden.

Produktdetails

• Verlag: Royal Society of Chemistry
• Seitenzahl: 480
• Erscheinungstermin: 11. November 2020
• Englisch
• ISBN-13: 9781839162541
• Artikelnr.: 70074700

Inhaltsangabe

Mechanisms and Maps of Nucleotide Excision Repair; Emerging Concepts on the
Early Steps of Base Excision Repair Pathway with a Focus on Gene
Expression; Base Excision Repair in Plants: Variations on a Theme; OGG1 at
the Crossroads of Inflammation and DNA Base Excision Repair; Fidelity
Mechanisms of DNA Polymerase Beta; DNA Damage Leads to Neurodegeneration
via Mitochondrial Dysfunction; Emerging Roles of Sirtuins in Chromatin
Regulation and DNA Repair Via their NAD+-dependent Activities; Unique Roles
of Human Translesion Synthesis DNA Polymerase; Replicative and
Transcriptional Bypass of Alkylated DNA Lesions in Human Cells; Mutational
Spectra Provide Insight into the Mechanisms Bridging DNA Damage to Genetic
Disease; Evolving DNA Repair Targets for Cancer Therapy; Basic,
Translational and Clinical Relevance of the DNA Repair and Redox Signaling
Protein APE1 in Human Diseases; The role of PARP and the therapeutic
potential of PARP inhibitors in cancer; Translating DNA Adduct Knowledge to
Human Prevention Trials; DNA Damage and the Maintenance of Nuclear Genome
Integrity in Aging and Associated Phenotypes; Gamma- and Ion-beam DNA
Radiation Damage: Theory and Experiment;