DNA Repair and Cancer (eBook, PDF)

From Bench to Clinic
Redaktion: Madhusudan, Srinivasan; Wilson III, David M.

• Format: PDF

Produktbeschreibung

DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 718
• Erscheinungstermin: 22. Januar 2013
• Englisch
• ISBN-13: 9781466577442
• Artikelnr.: 40068416

Autorenporträt

Srinivasan Madhusudan, David M. Wilson III

Inhaltsangabe

Overview of DNA Repair Pathways. Longevity Assurance by Genome Maintenance.
Genome Instability of Cancer: Biological Predictions and Clinical
Implications. Radiation Induced DNA Damage, Repair and Therapeutics.
Chemotherapeutic Alkylating Agents in Cancer Treatment.
O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and
Therapy. DNA Mismatch Repair: It's Role in Human. Carcinogenesis and as a
Predictive and/or Prognostic Biomarker for Cancer Therapy. DNA Base
Excision Repair Therapeutics: Summary of Targets with a Focus on APE1.
Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer.
Susceptibility. Fanconi Anemia, Interstrand Cross-link Repair and Cancer.
Functions of Translesion DNA Polymerases: Implications for Cancer Risk and
Opportunities as Therapeutic Targets. p53 in DNA Damage, Repair and Cancer
Therapeutics. ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation
in Cancer Therapy. The BRCA1-BRCA2 Pathway of Homologous Recombination and
the Opportunity for Synthetic Lethal Approaches to Cancer Therapy. PARP and
PARP Inhibitor Therapeutics. Tumor Genetics and Personalized Medicine. The
Tumor Microenvironment and DNA Repair: Implications for Cancer Progression
and Treatment. Early Phase Clinical Trials using DNA Repair Inhibitors:
Lessons Learnt.