Drug Development (eBook, PDF)

Molecular Targets for GI Diseases
Redaktion: Gaginella, Timothy S.; Guglietta, Antonio

• Format: PDF

Produktbeschreibung

Drug Development: Molecular Targets for Gastrointestinal Disease brings together a panel of distinguished experts to critically review the many promising new areas of gastrointestinal pharmacology at the molecular level. Key chapters discuss such major themes as the cyclooxygenase-2 inhibitors, the complexities of nitric oxide pathways in the gut, and the influence of cytokines on inflammatory bowel disease, as well as new opportunities for pharmacotherapy, including peptide growth factors, tachykinins-particularly substance P and neurokinins-cholecystokinin receptors, and serotonin. Also examined as possible sites for treating motility disorders and visceral pain are the opioid receptors residing in the gut, and the H3-receptor agonists for treating gut inflammation and pain. Drug Development: Molecular Targets for Gastrointestinal Disease provides a comprehensive review of today's molecular pharmacological approaches to the discovery and development of novel drugs for gastrointestinal and liver diseases. Its extensive references, richly experienced contributors, and cutting-edge syntheses of past, present, and emergent research establish the book as an essential resource for all pharmacologists, medicinal chemists, and clinicians seeking more powerful drugs for the prevention and treatment of gastrointestinal disorders.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 278
• Erscheinungstermin: 1. September 1999
• Englisch
• ISBN-13: 9781592592029
• Artikelnr.: 44047373

Inhaltsangabe

1 The Arachidonic Acid Pathway: New Molecules and Enzymes.- 2 Therapeutic Implications of the Nitric Oxide Pathway in Gastrointestinal Diseases.- 3 Cytokines: Opportunities for Therapeutic Intervention.- 4 Peptide Growth Factors in Gastrointestinal Disorder Therapeutics.- 5 Tachykinins: From Basic Concepts to Therapeutic Implications.- 6 CCKA Receptors in Gastrointestinal Disorders: New Therapeutic Implications.- 7 5-HT3/5-HT4 Receptors in Motility Disorders: New Therapeutic Agents.- 8 Opioid Receptors: Targets for New Gastrointestinal Drug Development.- 9 The Histamine H3 Receptor: Pharmacotherapy Targets in Gastrointestinal Disorders.

Rezensionen

"The book focuses on specific molecules and the drugs that act on them, their receptors, metabolism or synthesis. . . a useful text for investigators of GI function and for pharmacologists interested in therapeutic compounds, their actions and targets."-Trends in Pharmaceutical Sciences