Drug Discovery from Natural Products (eBook, PDF)

Redaktion: Genilloud, Olga; Vicente, Francisca

• Format: PDF

Produktdetails

• Verlag: RSC
• Seitenzahl: 432
• Erscheinungstermin: 21. August 2012
• Englisch
• ISBN-13: 9781849734950
• Artikelnr.: 44762289

Autorenporträt

Olga Genilloud obtained her Ph.D. in Chemistry (Biochemistry and Molecular Genetics) in 1988 from the Universidad Complutense de Madrid, Spain. After a short stay at the Microbiology Department at Harvard Medical School in Boston, in 1989 she joined the Centro de Investigacion Basica de Espana (CIBE), at Merck Sharp and Dohme in Spain, where she has led for nineteen years the discovery of bacterial natural products as new leads for drug development. In February 2009 she was appointed Scientific Director of Fundacion MEDINA. She has an extended list of publications, book chapters and patents derived from her contributions to the discovery of novel compounds and the application of new molecular tools in Natural Products mining. In February 2009, she joined the Fundacion MEDINA as Area Head of the Screening and Target Validation Department. Francisca Vicente has a Ph.D. in Biology and Molecular Genetics (1986, Universidad Autonoma de Madrid ) and more than 10 years experience in R&D, managing teams and working in the multidisciplinary environment of multinational pharmacy (Merck Sharp and Dohme, Spain) and other research centres (Institute Pasteur, and Hospital Necker, France). She has been in charge of the design, implementation, and supervision of many R&D projects. She is experienced in identifying and managing the economic resources for developing new scientific and technological projects. She has coordinated and managed national and international research groups. In February 2009, she joined the Fundacion MEDINA as Area Head of the Screening and Target Validation Department.

Inhaltsangabe

Introduction; Part one: Semisynthesis/ synthesis de novo of NPs:
Semisynthesis approach of Ecteinascidin 743 (ET-743, Yondelis«);
Chondramides and Chivosazoles - Two metabolites which interfere with the
actin cytoskeleton; Class III lantibiotics - an emerging family of
thioether containing peptidesMutant manufacturers; progress in enhancing
the neurotrophic effects of natural FKBP ligands; Part two: Engineering NP
synthetic pathways and genome mining: biosynthesis of indolocarbazole
alkaloids and generation of novel derivatives by combinatorial
biosynthesis; new lantibiotics from natural and engineered strains; mining
microbial genomes for metabolic products of cryptic pathways; mining
cyanobacterial genomes for drug-like and bioactive natural products;
pigenetic approaches to natural product synthesis in fungi; Part three: New
methodologies and screening technologies for the exploitation of microbial
resources: novel approaches for exploiting microbial resources at Fundacion
MEDINA; discovery and development of Platensimycin and Platencin; coupling
chemical genomics and natural products: the discovery of parnafungins and
novel antifungal leads; Part four: Novel microbial natural products and
derivatives: Retapamulin-a first-in-class pleuromutilin antibiotic; natural
products: new agents against MDR tuberculosis; the contribution of marine
chemistry in the field of antimalarial research; epothilones as lead
structures for new anticancer drugs; future challenges.