Jack P. Uetrecht, William Trager

Drug Metabolism (eBook, PDF)

Chemical and Enzymatic Aspects

• Format: PDF

Produktbeschreibung

In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structure and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This title is a comprehensive guide for recognizing the chemical underpinnings of drug metabolism. While there are numerous resources available to medicinal chemists for understanding drug structure, and to pharmacologists for discerning drug metabolism from a biological standpoint, no resource currently exists that links the chemical and biological aspects in language accessible to both-making it challenging for both groups to fully comprehend how a drug is metabolized, as well as the potential effects of the metabolites. Drug Metabolism: Chemical and Enzymatic Aspects provides extensive material to help understand drug metabolism within a biological context, and for predicting and mitigating adverse drug reactions.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 192
• Erscheinungstermin: 20. Juni 2007
• Englisch
• ISBN-13: 9780849375965
• Artikelnr.: 52849538

Autorenporträt

JACK P. UETRECHT is Professor of Pharmacy and Medicine and the Canada Research Chair in Adverse Drug Reactions, University of Toronto, Ontario, Canada. The chair of the Health Canada Scientific Advisory Panel for Hepatotoxicity and Fellow of the Canadian Academy of Health Sciences, Dr. Uetrecht's research is focused on the role of reactive metabolites in immune-mediated and other types of idiosyncratic adverse drug reactions. He serves on the editorial board of Chemical Research in Toxicology, Current Drug Metabolism, Drug Metabolism Letters, Drug Metabolism Reviews, Expert Opinion on Drug Metabolism and Toxicology, and Journal of Immunotoxicology. Dr. Uetrecht received his Ph.D. degree (1972) in organic chemistry from Cornell University, Ithaca, New York and his M.D. degree (1975) from Ohio State University, Columbus. WILLIAM TRAGER is Professor of Medicinal Chemistry, Emeritus, School of Pharmacy, University of Washington, Seattle. His primary research contributions encompass various aspects of drug metabolism, including the molecular basis of metabolically-based drug interactions, quantitative mass spectrometry using stable isotope, and stereoselective metabolism. During his career, he also served as an NIH study section committee member, science advisor to the Seattle FDA laboratory, department chairman, and member of numerous editorial boards. Dr. Trager received the B.Sc. degree in chemistry from the University of San Francisco, California and the Ph.D. degree in medicinal chemistry from the University of Washington, Seattle.