Drug Targeting (eBook, PDF)

Strategies, Principles, and Applications
Redaktion: Francis, G. E.

• Format: PDF

Produktbeschreibung

In Drug Targeting: Strategies, Methods, and Protocls, Gillian E. Francis and Cristina Delgado have assembled an outstanding collection of leading-edge protocols for drug targeting studies. In addition to providing detailed step-by-step instructions, the highly experienced authors review the principal current targeting strategies, discuss how to build the constructs, examine theoretical considerations relevant to solid tumors, and describe experimental and clinical applications of targeted drug delivery systems. Also presented are new chemical and biological approaches to the preparation of targeted biopharmaceuticals, including ribonuclease-antibody chimeras, bispecific antibodies, enzyme-antibody conjugates, and folate-bearing conjugates. Applications include the targeting of myocardial infarctions using liposomal systems, the use of monoclonal antibodies to target malaria and HIV-infected cells, the targeting of fusion proteins to leukemias and lymphomas, the use of antioxidant enzyme-antibody conjugates to target the pulmonary endothelium, as well as methods addressing both the active and passive targeting of tumors. Comprehensive and innovative, Drug Targeting: Strategies, Methods, and Protocols documents in practical detail the major new chemical and biological targeting methods now being used to produce today's emerging rich array of novel diagnostic agents and promising biopharmaceuticals.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 318
• Erscheinungstermin: 2. Februar 2008
• Englisch
• ISBN-13: 9781592590759
• Artikelnr.: 64701795

Inhaltsangabe

Strategies.- Chemical Construction of Immunotoxins.- Construction of Ribonuclease-Antibody Conjugates for Selective Cytotoxicity.- Intracellular Targeting Using Bispecific Antibodies.- Antibody Conjugation Methods for Active Targeting of Liposomes.- Folate as a Targeting Device for Proteins Utilizing Folate Receptor-Mediated Endocytosis.- Preparation of Recombinant RNase Single-Chain Antibody Fusion Proteins.- Theoretical Aspects.- Practical Considerations in the Exploitation of Passive Tumor Targeting.- Effect of Dose, Molecular Size, and Binding Affinity on Uptake of Antibodies.- Inhibition of Tumor Blood Flow.- Applications.- 10 Targeting in Myocardial Infarction.- 11 Targeting HIV-Infected Cells.- 12 Making Fusion Toxins to Target Leukemia and Lymphoma.- Antibody-Bearing Liposomes as Chloroquine Vehicles in Treatment of Murine Malaria.- 14 Immunotargeting of Catalase to the Pulmonary Vascular Endothelium.- 15 Targeted Gene Transfer.