Drug Transporters (eBook, PDF)

Volume 1: Role and Importance in ADME and Drug Development
Redaktion: Nicholls, Glynis; Youdim, Kuresh

• Format: PDF

Produktbeschreibung

Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. In this first volume on Drug Transporters, the current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics are comprehensively reviewed. The second volume of the book is specifically dedicated to emerging science and technologies, highlighting potential areas for future advances within the drug transporter field.

The topics covered in both volumes ensure that all relevant aspects of transporters are described across the drug development process, from in silico models and preclinical tools through to the potential impact of transporters in the clinic. Contributions are included from expert leaders in the field, at-the-bench industrial scientists, renowned academics and international regulators. Case studies and emerging developments are highlighted, together with the merits and limitations of the available methods and tools, and extensive references to reviews on specific in-depth topics are also included for those wishing to pursue their knowledge further.

As such, this text serves as an essential handbook of information for postgraduate students, academics, industrial scientists and regulators who wish to understand the role of transporters in absorption, distribution, metabolism, and excretion processes. In addition, it is also a useful reference tool on the models and calculations necessary to predict their effect on human pharmacokinetics and pharmacodynamics.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 463
• Erscheinungstermin: 16. August 2016
• Englisch
• ISBN-13: 9781782623793
• Artikelnr.: 46760120

Autorenporträt

Dr Glynis Nicholls has over 18 years experience within the pharmaceutical field in both academia and industry (including 7 years at GlaxoSmithKline and 5 years at AstraZeneca), specializing in drug transporter science from discovery through to clinical development. Dr Nicholls has played a leading role in writing and implementing internal transporter strategies within the industry, as well as collaborating across multiple international locations with internal and external colleagues on transporter-related projects and scientific developments, including PhD projects. Dr Kuresh Youdim has 9 years academic experience in the field of nutrition and neuroscience, plus 10 years pharmaceutical experience across multiple disciplines within drug discovery and development (including 8 years at Pfizer and 2 years at Roche) predominantly in the field of drug-drug interactions and PBPK modelling.

Inhaltsangabe

Overview of drug transporter families and their role in drug development
Liver transporters and their involvement in the hepatocellular uptake and export systems of organic anions
Intestinal transporters
Kidney transporters
CNS transporters
Lung transporters
The use of in vitro and in silico systems for investigating transporter interactions
The use of transgenic and knockout in vivo systems for investigating transporter interactions
Modelling and simulation of transporter interactions
Clinical Drug-Drug Interactions: An industrial Pharmaceutical Perspective
Regulatory requirements, Labelling and Drug Transporters
Recent Advances and Emerging Technologies
Bioinformatics
Regulation of transporters
Transporter Pharmacogenomics
Transporter Imaging
Transporters and Proteomics