J. De La Torre

Dynamics of Brain Monoamines (eBook, PDF)

• Format: PDF

Produktbeschreibung

The noted French physiologist Claude Bernard was fond of noting that "experimental ideas are often born by chance, with the help of some casual observation. " If history teaches us, we realize that this statement is as true today as it was 100 years ago. Today, however, we are luckier. We have, generally, some basis from previous work so that we can follow a line of research and thus provide even our most fundamental studies with an air of scientific respectability. Present-day research is rather like the working of a giant crossword puzzle where some of the letters or even words have been com pleted and the approach toward a relatively confident solution is a matter of juggling a series of permutations. I often wonder, though, how it was for the early brain researchers, who had very few letters, and, even less, no words, completed in their research puzzles to augment intelligent casual observation. By "early," I refer to nineteenth or early twentieth century investigators-men like Cajal, Sherrington, Pavlov, and Sechenov, whose investigations did more to advance their field in a span of 50 years than all of the cumulative previous work done on the brain and nervous system since the ancient Greeks.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 210
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781468419443
• Artikelnr.: 44058919

Inhaltsangabe

1. Metabolism of Monoamines.- 1.1. Biochemistry of Catecholamines in Brain.- 1.2. Biochemistry of 5-Hydroxytryptamine (Serotonin).- 1.3. Inactivation of Monoamines.- 2. Methods of Studying Cerebral Monoamines and Their Enzymes.- 2.1. Evaluation of Metabolites Excreted in Urine.- 2.2. Labeling and Autoradiographic Study of Monoamines.- 2.3. Ultrastructures: Electron Microscope Studies.- 2.4. Histochemical Fluorescence Method.- 3. Normal and Abnormal Physiology of Monoamines in the Central Nervous System.- 3.1. Monoamine Uptake and Distribution in Brain.- 3.2. Localization of Intraneuronal and Diffuse Monoamines.- 3.3. Localization of Brain Monoamine Nerve Terminals.- 3.4. Monoamines as Transmitters in the Central Nervous System.- 3.5. Neuropharmacology and Behavior.- 3.6. Inhibition and Release of Monoamines by Drugs.- 3.7. Sleep Mechanisms.- 3.8. Blood-Brain Barrier.- 4. Neuropsychopathology.- 4.1. Genetic Factors.- 4.2. Metabolism in Psychoses.- 4.3. Neuropathological States.- Appendix: Abbreviations Used in Text.- References.