Vassilios Poulantzas

Effectiveness of LU-177-dotatate after selective catheterization of the hepatic artery in inoperable metastasized liver tumors (eBook, PDF)

• Format: PDF

Produktbeschreibung

Doctoral Thesis / Dissertation from the year 2016 in the subject Medicine - Neoplasms, Oncology, , language: Modern Greek, abstract: The aim of this study is to evaluate the effectiveness of Lu-177-DOTATATE infusions after selective catheterization of the hepatic artery in inoperable metastasised liver, sst2 receptor-positive neuroendocrine tumours due to the effect of ß-emission, minimising in parallel the toxicity of non-target tissue. The average dose per session administered monthly to each patient (14 cases in total) was 6.3±2.3 GBq. Repetitions did not exceed 6-fold. Response assessment was classified according to the Response Evaluating Criteria in Solid Tumours. CT/ MRI scans were performed as baseline before, during and after the end of treatment, and monthly ultrasound images for follow-up measurements. Toxicity (World Health Organization criteria) was measured using blood and urine tests of renal, hepatic and bone marrow function. ¿one patient was achieved complete response[CR], partial response[PR] was shown in 9/14 (65%), and disease stabilization[SD] in 2/14 (14%) patients; three patients (21.0%) did not respond [PD]. Grade 1 erythro-, leuko- and thrombo-cytopenia occurred in 8 cases, grade 2-3 in 4 cases and blood transfusion (grade 4) in 2. In unresectable metastatic liver lesions positive for somatostatin receptors repeated, trans-hepatic high doses of Lu-177-DOTA-TATE show an effective therapeutic outcome. No nephro- or liver-toxicity has so far been observed. The observed myelo- toxicity was appropriately managed.

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Produktdetails

• Verlag: GRIN Verlag
• Seitenzahl: 93
• Erscheinungstermin: 14. September 2016
• Griechisch
• ISBN-13: 9783668299238
• Artikelnr.: 47002999