Emerging Concepts in Ribosome Structure, Biogenesis, and Function (eBook, ePUB)

Redaktion: Kumar, Vijay

• Format: ePub

Produktbeschreibung

Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview on all parts in this process. The book begins with an introduction to the ribosome factory, its origin and its evolution of translation. Sections discuss subunits, RNA, protein components, and its emergence as a frontier research area for translational potential in cancer and other diseases. In addition, the book explores current developments in ribosome research, including the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes.

This book provides the emerging research on ribosomes, their biogenesis, and other important topics on structure and function. Therefore, it will serve as a resourceful introduction for both new researchers and those engaged in interdisciplinary ribosomal research.

• Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth
• Covers disorders related to the ribosome (ribosomopathies)
• Explains the significance of ribosome dysfunction in human diseases
• Includes commonly used methods to study ribosomes, such as polysome preparation, RNA analysis and proteomics, CryoEM, and Cell-free assays, along with proper illustrations

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 296
• Erscheinungstermin: 25. September 2021
• Englisch
• ISBN-13: 9780128167342
• Artikelnr.: 62636412

Autorenporträt

Dr. Vijay Kumar is currently Professor and J.C. Bose National Fellow in the Department of Molecular and Cellular Medicine at the Institute of Liver and Biliary Sciences (ILBS) in New Delhi, India. He received his PhD in Medical Sciences at All India Institute of Medical Sciences in New Delhi, India and pursued his post-doctoral studies in Molecular Biology at the Université Louis-Pasteur in Strasbourg, France. He has been working in the area of cancer biology for over three decades. His work has focused on signaling mechanisms, cell cycle, DNA replication, ribosomal RNA, and protein synthesis, and he has extensive knowledge of ribosome biogenesis and its involvement in cell transformation and cancerous growth. He has done pioneering work in the area of steroid hormone receptors, regulation of RNA polymerase I-dependent transcription and ribosome biogenesis, cell cycle regulation, hepatitis B virus and hepatocellular carcinoma, and hepatoprotective mechanisms of medicinal plants. H

is current research interest includes the role of microRNA in health and disease. Dr. Kumar is a recipient of several national awards and is a fellow of National Academy of Sciences, National Academy of Medical Sciences, and the National Academy of Agricultural Sciences of India.

Inhaltsangabe

1. Introduction to ribosome factory, origin and evolution of translation
2. Ribosome structure
3. rDNA gene structure, transcription and their co-regulation
4. Ribosomal proteins - their balanced production
5. Ribosome diversity
6. Ribosome cycle - Assembly, degradation, and recycling
7. Ribosomal biogenesis in eukaryotes
8. Protein biogenesis in prokaryotes
9. Translation - Process and control
10. Inhibitores of ribosome biogenesis in prokaryotes and eukaryotes
11. Ribosomopathies - A tree of pathologies with many roots and branches!
12. Ribosomal profiling - Diversity and applications