Endocrinology of the Lung (eBook, PDF)

Development and Surfactant Synthesis
Redaktion: Mendelson, Carole R.

• Format: PDF

Produktbeschreibung

During the past thirty years, great progress has been made in defining the roles of steroid, peptide, and polypeptide hormones in the processes of lung morphogenesis, differentiation of specialized cell types, and surfactant synthesis. In Endocrinology of the Lung, Carole Mendelson has assembled a panel of leading investigators to critically review the roles of various classes of endocrine, paracrine, and neuroendocrine factors in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung branching morphogenesis and the synthesis of surfactant glycerophospholipids and proteins. Also extensively examined are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. The model systems utilized in these studies range from whole animal to transgenic and gene-targeted mice, to organ and cell culture. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for investigators actively studying hormone action in pulmonary biology and medicine today.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 360
• Erscheinungstermin: 29. Mai 2000
• Englisch
• ISBN-13: 9781592590148
• Artikelnr.: 44053731

Inhaltsangabe

1 The Glucocorticoid Domain in the Lung and Mechanisms of Action.- 2 Fetal Responses to Glucocorticoids.- 3 Cyclic Adenosine Monophosphate and Glucocorticoid Regulation of Surfactant Protein-A Gene Expression.- 4 Hormonal Regulation of Surfactant Protein-B and Surfactant Protein-C Gene Expression in Fetal Lung.- 5 Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung.- 6 The Genetics of Glucocorticoid-Regulated Embryonic Lung Morphogenesis: A First Approximation of the Epigenetic Rules.- 7 Corticotropin-Releasing Hormone and the Lung.- 8 Sex Differences in Fetal Lung Development: Biology, Etiology, and Evolutionary Significance.- 9 Retinoids and Lung Development.- 10 Insulin and Lung Development.- 11 The Insulin-like Growth Factor System and Lung.- 12 Platelet-Derived Growth Factor and Lung Development.- 13 Transforming Growth Factor-? Receptor Signaling and Lung Development.- 14 Transgenic Mouse Models for the Study of Growth Factor Signaling During Lung Morphogenesis.- 15 Parathyroid Hormone-Related Protein.- 16 Role of Neuroendocrine Cells in Fetal and Postnatal Lung.

Rezensionen

"The book is well organized and generally well written, with fewer overlaps and disagreements between authors than is normally seen in a multiauthored book. This book provides a welcome review of the role of hormones in fetal lung maturation. The book succeeds in appealing to pulmonary and developmental biologists."-Doody's Health Sciences Book Review Journal "This book will be welcomed by neonatologists, pediatric endocrinologists consulting on neonatal wards, obstetricians and last but not least pulmonologists. To the best of my knowledge it brings together for the the first time the latest knowledge on the role of hormones especially glucocorticoids on lung development and surfactant production." -Journal of Pediatric Endocrinology & Metabolism.