Environmental Epigenomics in Health and Disease (eBook, PDF)

Epigenetics and Disease Origins
Redaktion: Jirtle, Randy L; Tyson, Frederick L.

• Format: PDF

Produktbeschreibung

Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 302
• Erscheinungstermin: 16. Mai 2013
• Englisch
• ISBN-13: 9783642233807
• Artikelnr.: 43792141

Inhaltsangabe

Preface Frederick L. Tyson.
 Fetal Origins of Adult Disease Susceptibility.
1)      Randy L. Jirtle
Epigenetics: How Genes and Environment Interact.
2)      Peter D. Gluckman, Felicia M. Low, and Mark A. Hanson
Developmental Epigenomics and Metabolic Disease.
3)      Susan K. Murphy, and Cathrine Hoyo
Sculpting Our Future: Environmental Nudging of the Imprintome.
 Epigenetics and Environmental Exposures.
1)      Christopher Faulk, and Dana C. Dolinoy
Complex Phenotypes: Epigenetic Manifestation of Environmental Exposure.
2)      Olga Kovalchuk
Epigenetic Effects of Ionizing Radiation.
3)      Kenneth S. Ramos, Ivo Teneng, Diego E. Montoya
Durango, Pasano Bojang, Mark T. Haeberle, Irma N. Ramos, Vilius Stribinskis, and Ted Kalbfleisch
The Intersection of Genetics and Epigenetics: Reactivation of Mammalian LINE
1 Retrotransposons by Environmental Injury.
 Epigenetics, Gene Regulation, and Stem Cells.
1)      John M. Denu
Environmental Impact on Epigenetic Histone Language.
2)      Aleksandra B. Adomas, and Paul A. Wade
Chromatin Structure and Gene Expression
Function Follows Form.
3)      R. David Hawkins, and Bing Ren
Epigenetics of Pluripotency.
 Epigenetic Transgenerational Inheritance.
1)      Luan Wang, Xiangyi Lu, and Douglas M. Ruden
Transgenerational Epigenetic Inheritance in Drosophila.
2)      Michael K. Skinner
Environmental Epigenetics and Epigenetic Transgenerational Inheritance.
3)      Marcus E. Pembrey, Lars O. Bygren, and Jean Golding
The Nature of Human Transgenerational Responses.
Subject Index