Epigenetic Drug Discovery (eBook, ePUB)

Redaktion: Sippl, Wolfgang; Jung, Manfred

• Format: ePub

Produktbeschreibung

Presents new targets and strategies for one of the most exciting frontiers in pharmaceutical research Epigenetic Drug Discovery provides a broad overview of epigenetic approaches in drug research, combining methods and strategies with individual targets. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. The second part of Epigenetic Drug Discovery discusses recently developed methods for examining epigenetic targets, as well as new structural biology and computational approaches. Topics include the structural biology of epigenetic targets, computer-based approaches, mass spectrometry approaches, peptide microarrays for epigenetic targets, and chemical probe development. The third part revisits some of the early epigenetic targets and adds a number of new and still largely unexplored targets, such as sirtuins, methyl-lysine reader proteins, and parasitic targets. It also covers HDAC inhibitors, methyltransferases, demethylases LSD1 and JMJD, histone acetyltransferases, BRD bromodomains, and DNA modifying enzymes. -The latest strategies and targets for epigenetic drug discovery -Tailored to the needs of drug developers working in small and large pharmaceutical companies -Offers comprehensive coverage of the subject and all the techniques and applications within the field Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

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Produktdetails

• Verlag: Wiley-VCH
• Seitenzahl: 487
• Erscheinungstermin: 26. November 2018
• Englisch
• ISBN-13: 9783527809264
• Artikelnr.: 56980142