Epigenetic Regulation of Lymphocyte Development (eBook, PDF)

Redaktion: Murre, Cornelis

• Format: PDF

Produktbeschreibung

Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 194
• Erscheinungstermin: 7. Februar 2012
• Englisch
• ISBN-13: 9783642241031
• Artikelnr.: 37370854

Inhaltsangabe

Preface.
Roles of lineage
determining transcription factors in establishing open chromatin
lessons from high
throughput studies.
B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1.
Epigenetic features that regulate IgH locus recombination and expression.
Local and global epigenetic regulation of V(D)J recombination.
Genetic and Epigenetic Regulation of TCRbeta Gene Assembly.
T
cell identity and epigenetic memory.
Encoding stability versus flexibility:  Lessons learned from examining epigenetics in T helper cell differentiation.
The epigenetic landscape of lineage choice: lessons from the heritability of Cd4 and Cd8 expression.
  Subject Index