Epigenetics for Drug Discovery (eBook, PDF)

Redaktion: Carey, Nessa

• Format: PDF

Produktbeschreibung

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington's disease and from inflammation to sickle cell anaemia.

The book is structured in three main sections. The first section introduces epigenetics and explain its importance at both a phenomenological and molecular level. The second section goes on to review how each of the big breakthroughs in drug discovery in this field have developed, with a strong emphasis on case histories. The final section highlights the ongoing challenges in creating safe and efficacious epigenetic drugs.

Written and edited by experts within the field from both industry and academia, this book provides an invaluable guide to this developing field for medicinal chemists working in academia and in the pharmaceutical industry.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 321
• Erscheinungstermin: 20. November 2015
• Englisch
• ISBN-13: 9781782628484
• Artikelnr.: 44763685

Inhaltsangabe

Epigenetics - What it is and Why it Matters
Enzyme and Protein Families that Regulate Histone Modifications and Crosstalk
Epigenetics and Disease
Targeting DNA Methylation
Targeting Histone Acetylation
Targeting Histone Lysine Methyltransferases in Cancer
Targeting Non-Acetylation Histone Erasers
Progress in Targeting Epigenetic Readers
Who will Bebefit from Epigenetic Drugs
Dosing - When Less Is More
Histone Methyltransferase Activity Assays
Safety Considerations for Epigenetic Mechanisms as Drug Targets: Are Existing Toxicology Studies Fit for Purpose?