Epigenomics (eBook, ePUB)

From Chromatin Biology to Therapeutics
Redaktion: Appasani, Krishnarao

• Format: ePub

Produktbeschreibung

Understanding mechanisms of gene regulation that are independent of the DNA sequence itself - epigenetics - has the potential to overthrow long-held views on central topics in biology, such as the biology of disease or the evolution of species. High throughput technologies reveal epigenetic mechanisms at a genome-wide level, giving rise to epigenomics as a new discipline with a distinct set of research questions and methods. Leading experts from academia, the biotechnology and pharmaceutical industries explain the role of epigenomics in a wide range of contexts, covering basic chromatin biology, imprinting at a genome-wide level, and epigenomics in disease biology and epidemiology. Details on assays and sequencing technology serve as an up-to-date overview of the available technological tool kit. A reliable guide for newcomers to the field as well as experienced scientists, this is a unique resource for anyone interested in applying the power of twenty-first-century genomics to epigenetic studies.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 2. August 2012
• Englisch
• ISBN-13: 9781139539760
• Artikelnr.: 52849260

Inhaltsangabe

List of contributors; Foreword; Preface; Part I. Basics of Chromatin
Biology and Biochemistry: 1. Introduction to epigenomics; 2. Epigenetics
and its historical perspectives; 3. Functional networks of human epigenetic
factors; 4. Nucleosome positioning in promoters: significance and open
questions; 5. Chemical reporters of protein methylation and acetylation; 6.
Long non-coding RNA in epigenetic gene silencing; Part II. Epigenomic
Imprinting and Stem Cells: 7. Active DNA demethylation - the enigma starts
in the zygote; 8. Histone modifications of lineage specific genes in human
embryonic stem cells during in vitro differentiation; 9. Epigenetic
stability of human pluripotent stem cells; 10. Impact of CpG methylation in
addressing adipose derived stem cell differentiation towards the cardiac
phenotype; 11. Regulation of stem cell epigenome by REST; 12. MicroRNAs in
embryonic stem cells; 13. Regulation of timing of replication; Part III.
Epigenomic Assays and Sequencing Technology: 14. Detection of CpG
methylation patterns by affinity capture methods; 15. Genome-wide ChIP-DSL
profiling of promoter methylation patterns associated with cancer and stem
cell differentiation; 16. Quantitative, high-resolution CpG methylation
assays on the pyrosequencing platform; 17. DNA methylation profiling using
Illumina BeadArray platform; 18. Advances in capillary
electrophoresis-based methods for DNA methylation analysis; 19. Genome-wide
methylome analysis based on new HT sequencing technology; 20. 3-D
quantitative DNA methylation imaging for chromatin texture analysis in
pharmacoepigenomics and toxicoepigenomics; Part IV. Epigenomics in Disease
Biology: 21. Cancer classification by genome-wide and quantitative DNA
methylation analyses; 22. Promoter CpG island methylation in colorectal
cancer: biology and clinical applications; 23. The epigenetic profile of
bladder cancer; 24. Genome-scale DNA methylation analyses of cancer in
children; 25. The epigenetics of facioscapulohumeral muscular dystrophy;
26. Modulating histone acetylation with inhibitors and activators; Part V.
Epigenomics in Neurodegenerative Diseases: 27. Study design considerations
in epigenetic studies of neuropsychiatric disease; 28. Epigenetic
regulation in human neurodevelopmental disorders including autism, Rett
syndrome and epilepsy; 29. The neurobiology of chromatin-associated
mechanisms in the context of psychosis and mood spectrum disorders; 30.
Genome-wide DNA methylation analysis in patients with familial ATR-X mental
retardation syndrome; 31. Kinases and phosphatases in the epigenetic
regulation of cognitive functions; Part VI. Epigenetic Variation,
Polymorphism and Epidemiological Perspectives: 32. Epigenetic effects of
childhood abuse on the human brain; 33. X-linked expressed SNPs and dosage
compensation; 34. Epigenomic diversity of colorectal cancer; 35. Epigenetic
epidemiology: transgenerational responses to the environment; Index.