Arthur J. Sytkowski

Erythropoietin (eBook, PDF)

Blood, Brain and Beyond

• Format: PDF

Produktbeschreibung

The use of Epo in medical practice is increasing constantly. It has revolutionized how we think of blood transfusion in medicine and surgery. Moreover, it has become widely known to scientists, physicians, biotech and pharmaceutical executives and the general public. Additionally, the past ten years have seen important advances in our knowledge and understanding of its action both within and outside of the hematopoietic system. Until now, there has been no single source that contains up-to-date information on Epo addressing the array of subjects that this book presents. The book covers all aspects from developmental biology to specific topics such as medical applications of recombinant Epo, receptor biology, mechanisms of Epo activity, structure/activity relationship, disease states and important actions on non-hematopoietic organs and tissues, including the central nervous system, heart, gastrointestinal tract, reproductive organs and endothelium.

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Produktdetails

• Verlag: Wiley-VCH
• Seitenzahl: 224
• Erscheinungstermin: 6. März 2006
• Englisch
• ISBN-13: 9783527605439
• Artikelnr.: 37349636

Autorenporträt

Dr. Arthur Sytkowski received his Doctor of Medicine from the Medical College of Wisconsin and worked as a Research Associate in the Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute (NHLBI), NIH, Bethesda. In 1977, he joined Harvard Medical School, and established his research on the structure and function of human erythropoietin. Current research interests include therapeutic protein engineering, the control of blood cell differentiation, mechanisms of neoplasia, biological effects of microgravity, ligand/receptor biochemistry, growth factor signal transduction, gene regulation and cancer chemoprevention.

Inhaltsangabe

From the contents:
1. Introduction and History2. Developmental Biology of Erythropoiesis and Erythropoietin Production3. Regulation of the Erythropoietin Gene: A Paradigm for Hypoxia Dependent Genes4. Physiology and Metabolism of Erythropoietin 5. Biochemistry and Protein Structure 6. Receptor Biology and Signal Transduction 7. Clinical Disorders of Erythropoietin and its Receptor8. Recombinant Erythropoietin and the Treatment of Anemia9. Function of Erythropoietin Outside of Hematopoiesis10. Bioanalytics, doping11. Future developments-experimental therapeutics

Rezensionen

"... in einem einzigen Buch den weiten Informationsbereich über die Wirkweise und Anwendung von Erythropoietin komprimiert."
-- Arzneimittel-Forschung