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This unique new book uses a series of focussed questions, comprehensive literature evaluations and structured grades of recommendation to provide evidence for the treatment of hematological disorders, both malignant and benign. With contributions from leading international experts who have a real understanding of evidence-based medicine the book provides comprehensive reviews accompanied by clinical commentaries and recommendations on the best treatment regimes to adopt for individual patients. The book is split into two sections: the first examines the methodology underlying evidence based…mehr
This unique new book uses a series of focussed questions, comprehensive literature evaluations and structured grades of recommendation to provide evidence for the treatment of hematological disorders, both malignant and benign. With contributions from leading international experts who have a real understanding of evidence-based medicine the book provides comprehensive reviews accompanied by clinical commentaries and recommendations on the best treatment regimes to adopt for individual patients. The book is split into two sections: the first examines the methodology underlying evidence based practice, and the second concentrates on the clinical practice of hematology, providing current "best evidence" to guide practice in a series of well-defined clinical situations. This clinical reference is an invaluable source of evidence-based information distilled into guidance for clinical practice which will be welcomed by practitioners, trainees and associated health professionals.
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Autorenporträt
Mark A. Crowther, MD, MSc, FRCPC McMaster University, Hamilton, Ontario, Canada Jeff Ginsberg, MD, FRCPC, McMaster University, Hamilton, Ontario, Canada Holger J. Schünemann, MD, PhD, MSc, FACP, FCCP, Italian National Cancer Institute, Rome, Italy Ralph M. Meyer, MD, FRCPC Queen's University, Kingston, Ontario, Canada Richard Lottenberg, MD, FACP, University of Florida, Gainesville, FL, USA
Inhaltsangabe
List of Contributors vii Preface xi Part 1 A Guide to the Evidence Editor: Holger J. Schünemann 1 Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research 3 Holger J. Schünemann, Martin Stanulla, Jan L. Brozek, Gordon G. Guyatt 2 An Overview of Systematic Reviews 10 Martin Prins, Arina ten Cate-Hoek, Pieter Leffers 3 Interpreting Results in Clinical Research: Overview of measures of effect, measures of precision, and measures of diagnostic accuracy for clinicians and researchers 15 Marcello Di Nisio, Harry R. Büller, Patrick M. M. Bossuyt 4 Finding the Evidence in Hematology 23 K. Ann McKibbon, Cynthia J. Walker-Dilks, R. Brian Haynes 5 Applying EBM in Clinical Practice 32 Alessandro Squizzato, Walter Ageno, Davide Imberti 6 Using Evidence to Guide the Diagnosis of Disease 37 Lucas M. Bachmann, Holger J. Schünemann Part 2 Hemostasis and Thrombosis Editor: Jeff Ginsberg 7 Diagnosis of Deep Vein Thrombosis 49 Lori-Ann Linkins 8 The Diagnosis of Acute Pulmonary Embolism 56 Victor F. Tapson 9 Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism 65 Sam Schulman 10 Long-Term Anticoagulation in Venous Thromboembolism 73 Clive Kearon 11 Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism 88 Simon J. McRae, John W. Eikelboom 12 Inferior Vena Cava Interruption 99 Michael B. Streiff, Christine L. Hann 13 Management of Venous Thromboembolism in Pregnancy 110 Wee-Shian Chan 14 Pediatric Thrombosis 120 Anthony K. C. Chan, Paul Monagle 15 Bridging Anticoagulation in Patients Who Require Temporary Interruption of Warfarin for Surgery 124 James D. Douketis, Scott Kaatz 16 Evidence-based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura 131 Brian Boulmay, Craig S. Kitchens 17 Diagnosis and Management of Disseminated Intravascular Coagulation 138 Julia A. M. Anderson 18 Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders 145 Nigel S. Key, Alice D. Ma 19 Diagnosis and Management of Acquired Bleeding Disorders: Vitamin K Antagonists 152 Miguel A. Escobar 20 Diagnosis and Management of Heparin-Induced Thrombocytopenia 158 Theodore E. Warkentin, Andreas Greinacher 21 Management of Antiphospholipid Antibody Syndrome 168 Wendy Lim, Mark A. Crowther Part 3 Benign Hematologic Disorders Editor: Richard Lottenberg 22 Clinical Questions in Iron Overload 179 Antonello Pietrangelo, Nicola Magrini 23 Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia 189 Shivani Srivastava, Richard W. Childs 24 Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia 197 Marc S. Zumberg, Marc J. Kahn 25 Immune Thrombocytopenic Purpura 206 James N. George, Sara K. Vesely, George R. Buchanan 26 Neutropenia 215 David C. Dale 27 Hypereosinophilia: Primary and Secondary 221 Florence Roufosse, Michel Goldman, Elie Cogan 28 Porphyrias 229 Gagan Sood, Karl E. Anderson 29 Membrane and Enzyme Abnormalities of the Erythrocyte 238 Patrick G. Gallagher, Ernest Beutler 30 Sickle Cell Disease 244 Richard Lottenberg, Sally C. Davies 31 Evidence-based Treatment of Thalassemia Major 251 Issac Odame, Deborah Rund Part 4 Malignant Hematologic Disorders Editor: Ralph M. Meyer 32 Acute Lymphoblastic Leukemia in Adults 263 Stephen Couban, Andrea Kew 33 Acute Myeloid Leukemia in Adults: Remission Induction Therapy 268 Cara A. Rosenbaum, Richard A. Larson 34 Acute Myeloid Leukemia in Adults: Postremission Therapy 278 Cara A. Rosenbaum, Richard A. Larson 35 Current Areas of Controversy in the Treatment of Patients With Newly Diagnosed Acute Promyelocytic Leukemia 287 Martin S. Tallman, Syed A. Abutalib 36 Chronic Lymphocytic Leukemia 294 Bruce D. Cheson 37 Chronic Myeloid Leukemia 300 Irwin Walker 38 Selected Management of Patients with Myelodysplastic Syndromes 305 John M. Storring, Karen W. L. Yee 39 Evidence-based Treatment of Burkitt Lymphoma in Adults 311 John Gerecitano, David J. Straus 40 Primary Central Nervous System Lymphoma 317 Tamara Shenkier 41 Diffuse Large B-cell Lymphoma 327 Michael Crump 42 Follicular Lymphoma 334 Kevin Imrie, Matthew Cheung 43 Lymphoblastic Lymphoma 342 Tyler Y. Kang, John W. Sweetenham 44 Mantle Cell Lymphoma 347 C. Tom Kouroukis 45 Management of Patients with Peripheral T-cell Lymphoma 352 Kerry J. Savage 46 Selected Management Issues of Patients with Hodgkin Lymphoma 365 Ralph M. Meyer 47 Lymphocyte Predominant Hodgkin Lymphoma 372 Brandon McMahon, Jonathan W. Friedberg 48 Management of Patients with Essential Thrombocythemia 378 Guido Finazzi, Giovanni Barosi, Tiziano Barbui 49 Management of Patients with Polycythemia Vera 385 Guido Finazzi, Roberto Marchioli, Tiziano Barbui 50 Evidence-based Review of Therapies in Multiple Myeloma 390 Michael Sebag, A. Keith Stewart 51 Management of Waldenstrom's Macroglobulinemia 396 Christine I. Chen 52 The Role of Hematopoietic Growth Factors in Managing Patients with Hematologic Malignancies 402 Heloisa P. Soares, Ambuj Kumar, Charles Bennett, Benjamin Djulbegovic Index 413
List of Contributors vii Preface xi Part 1 A Guide to the Evidence Editor: Holger J. Schünemann 1 Rating the Quality of Evidence and Making Recommendations: A Guide to the Spectrum of Clinical Research 3 Holger J. Schünemann, Martin Stanulla, Jan L. Brozek, Gordon G. Guyatt 2 An Overview of Systematic Reviews 10 Martin Prins, Arina ten Cate-Hoek, Pieter Leffers 3 Interpreting Results in Clinical Research: Overview of measures of effect, measures of precision, and measures of diagnostic accuracy for clinicians and researchers 15 Marcello Di Nisio, Harry R. Büller, Patrick M. M. Bossuyt 4 Finding the Evidence in Hematology 23 K. Ann McKibbon, Cynthia J. Walker-Dilks, R. Brian Haynes 5 Applying EBM in Clinical Practice 32 Alessandro Squizzato, Walter Ageno, Davide Imberti 6 Using Evidence to Guide the Diagnosis of Disease 37 Lucas M. Bachmann, Holger J. Schünemann Part 2 Hemostasis and Thrombosis Editor: Jeff Ginsberg 7 Diagnosis of Deep Vein Thrombosis 49 Lori-Ann Linkins 8 The Diagnosis of Acute Pulmonary Embolism 56 Victor F. Tapson 9 Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism 65 Sam Schulman 10 Long-Term Anticoagulation in Venous Thromboembolism 73 Clive Kearon 11 Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism 88 Simon J. McRae, John W. Eikelboom 12 Inferior Vena Cava Interruption 99 Michael B. Streiff, Christine L. Hann 13 Management of Venous Thromboembolism in Pregnancy 110 Wee-Shian Chan 14 Pediatric Thrombosis 120 Anthony K. C. Chan, Paul Monagle 15 Bridging Anticoagulation in Patients Who Require Temporary Interruption of Warfarin for Surgery 124 James D. Douketis, Scott Kaatz 16 Evidence-based Approach to the Diagnosis and Management of Thrombotic Thrombocytopenic Purpura 131 Brian Boulmay, Craig S. Kitchens 17 Diagnosis and Management of Disseminated Intravascular Coagulation 138 Julia A. M. Anderson 18 Diagnosis and Management of Hereditary Bleeding Disorders: Including Congenital/Acquired Platelet Function Disorders 145 Nigel S. Key, Alice D. Ma 19 Diagnosis and Management of Acquired Bleeding Disorders: Vitamin K Antagonists 152 Miguel A. Escobar 20 Diagnosis and Management of Heparin-Induced Thrombocytopenia 158 Theodore E. Warkentin, Andreas Greinacher 21 Management of Antiphospholipid Antibody Syndrome 168 Wendy Lim, Mark A. Crowther Part 3 Benign Hematologic Disorders Editor: Richard Lottenberg 22 Clinical Questions in Iron Overload 179 Antonello Pietrangelo, Nicola Magrini 23 Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, and Pure Red Cell Aplasia 189 Shivani Srivastava, Richard W. Childs 24 Acquired Anemias: Iron Deficiency, Cobalamin Deficiency, and Autoimmune Hemolytic Anemia 197 Marc S. Zumberg, Marc J. Kahn 25 Immune Thrombocytopenic Purpura 206 James N. George, Sara K. Vesely, George R. Buchanan 26 Neutropenia 215 David C. Dale 27 Hypereosinophilia: Primary and Secondary 221 Florence Roufosse, Michel Goldman, Elie Cogan 28 Porphyrias 229 Gagan Sood, Karl E. Anderson 29 Membrane and Enzyme Abnormalities of the Erythrocyte 238 Patrick G. Gallagher, Ernest Beutler 30 Sickle Cell Disease 244 Richard Lottenberg, Sally C. Davies 31 Evidence-based Treatment of Thalassemia Major 251 Issac Odame, Deborah Rund Part 4 Malignant Hematologic Disorders Editor: Ralph M. Meyer 32 Acute Lymphoblastic Leukemia in Adults 263 Stephen Couban, Andrea Kew 33 Acute Myeloid Leukemia in Adults: Remission Induction Therapy 268 Cara A. Rosenbaum, Richard A. Larson 34 Acute Myeloid Leukemia in Adults: Postremission Therapy 278 Cara A. Rosenbaum, Richard A. Larson 35 Current Areas of Controversy in the Treatment of Patients With Newly Diagnosed Acute Promyelocytic Leukemia 287 Martin S. Tallman, Syed A. Abutalib 36 Chronic Lymphocytic Leukemia 294 Bruce D. Cheson 37 Chronic Myeloid Leukemia 300 Irwin Walker 38 Selected Management of Patients with Myelodysplastic Syndromes 305 John M. Storring, Karen W. L. Yee 39 Evidence-based Treatment of Burkitt Lymphoma in Adults 311 John Gerecitano, David J. Straus 40 Primary Central Nervous System Lymphoma 317 Tamara Shenkier 41 Diffuse Large B-cell Lymphoma 327 Michael Crump 42 Follicular Lymphoma 334 Kevin Imrie, Matthew Cheung 43 Lymphoblastic Lymphoma 342 Tyler Y. Kang, John W. Sweetenham 44 Mantle Cell Lymphoma 347 C. Tom Kouroukis 45 Management of Patients with Peripheral T-cell Lymphoma 352 Kerry J. Savage 46 Selected Management Issues of Patients with Hodgkin Lymphoma 365 Ralph M. Meyer 47 Lymphocyte Predominant Hodgkin Lymphoma 372 Brandon McMahon, Jonathan W. Friedberg 48 Management of Patients with Essential Thrombocythemia 378 Guido Finazzi, Giovanni Barosi, Tiziano Barbui 49 Management of Patients with Polycythemia Vera 385 Guido Finazzi, Roberto Marchioli, Tiziano Barbui 50 Evidence-based Review of Therapies in Multiple Myeloma 390 Michael Sebag, A. Keith Stewart 51 Management of Waldenstrom's Macroglobulinemia 396 Christine I. Chen 52 The Role of Hematopoietic Growth Factors in Managing Patients with Hematologic Malignancies 402 Heloisa P. Soares, Ambuj Kumar, Charles Bennett, Benjamin Djulbegovic Index 413
Rezensionen
"This book is an excellent collection of current best practices in hematology. It should appeal to all who have to deal with everyday challenges in blood diseases." (Journal of Tropical Pediatrics, June 2009)
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