Evolving Methods for Macromolecular Crystallography (eBook, PDF)

The Structural Path to the Understanding of the Mechanism of Action of CBRN Agents
Redaktion: Read, Randy J.; Sussman, Joel L.

• Format: PDF

Produktbeschreibung

This volume draws on the expertise of leaders in the field of macromolecular crystallography to illuminate the dramatic developments that are accelerating progress in structural biology. Their contributions span the range of techniques from crystallization through data collection, structure solution and analysis. The book shows how modern high-throughput methods are contributing to a deeper understanding of medical problems.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 192
• Erscheinungstermin: 20. Juli 2007
• Englisch
• ISBN-13: 9781402063169
• Artikelnr.: 37356723

Autorenporträt

Randy J. Read, University of Cambridge, UK / Joel L. Sussman, Weizmann Institute of Science, Rehovot, Israel

Inhaltsangabe

Succeeding with seeding: some practical advice.- Expression, purification, and crystallisationof membrane proteins.- Macromolecular cryo-crystallography.- Processing diffraction data with mosflm.- Sad phasing: basic concepts and high-throughput.- Likelihood-based experimental phasing in phaser.- Stochastic molecular replacement.- Likelihood-based molecular replacement in phaser.- Automated structure determination with phenix.- Density Modification In Main.- Ab initio phasing starting from low resolution.- Structural genomics of mycobacterium tuberculosis: a search for function and new drug targets.- Three-dimensional domain swapping and its relevance to conformational diseases.- Structural bioinformatics: from protein structure to function.- Single-particle imaging.

Rezensionen

From the reviews:

"The book is a summary of the proceedings on 'Evolving Methods for Macromolecular Crystallography' held in 2005. ... it is a welcome addition to the crystallographer's bookshelf with contributions by a number of experts in their field."

(Miroslav Papiz, Crystallography Reviews, Vol. 15 (2), 2009)