Extracellular Vesicles in Health and Disease (eBook, PDF)

Redaktion: Harrison, Paul; Sargent, Ian L.; Gardiner, Chris

• Format: PDF

Produktbeschreibung

Interest in the role of extracellular vesicles (microvesicles and exosomes) is expanding rapidly. It is now apparent that far from being merely cellular debris, these vesicles play a key role in cell-to-cell communication and signaling. Moreover, they are significantly elevated in a number of diseases. This raises the question of their direct role

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 482
• Erscheinungstermin: 2. Mai 2014
• Englisch
• ISBN-13: 9789814411998
• Artikelnr.: 41077515

Autorenporträt

Paul Harrison is the Healing Foundation senior lecturer within the School of Immunity and Infection at the University of Birmingham, UK. He is a former president of the British Society of Haemostasis and Thrombosis. He has published over 120 papers and book chapters/reviews in his field. In 2010, Paul was featured as one of the top 100 healthcare scientists in the United Kingdom by the Department of Health. He is also an associate editor of the Journal of Extracellular Vesicles and a member of the editorial board of Platelets and the Journal of Thrombosis and Haemostasis. Chris Gardiner is scientific secretary of the British Society for Haemostasis and Thrombosis and a board member of both the International Society of Extracellular Vesicles and International Society of Laboratory Hematology. He serves on the editorial board of the Journal of Extracellular Vesicles and the International Journal of Thrombosis and Haemostasis. He has vast experience on the measurement and characterization of extracellular vesicles in the early detection of human disease. Ian L. Sargent is professor of reproductive science in the Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK. He has worked in the field of reproductive immunology and trophoblast biology for more than 30 years and has over 150 publications on a wide range of topics including pre-eclampsia, feto-maternal cell traffic, HLA-G, and early human embryo development and implantation. A major focus of his work has been the isolation and characterization of placental extracellular vesicles and their role in the pathogenesis of pre-eclampsia.

Inhaltsangabe

OVERVIEW. Overview of Extracellular Vesicles in Health and Disease. The
Biogenesis of Exosomes. Extracellular Vesicle-Mediated Epigenetic
Reprogramming of Cells. TECHNOLOGIES FOR MEASUREMENT OF EXTRACELLULAR
VESICLES. An Overview of Novel and Conventional Methods to Detect
Extracellular Vesicles. Standardization and Pre-Analytical Variables.
Procoagulant Assays. Capture Based Assays for Extracellular Vesicles within
the Blood. Flow Cytometry. Atomic Force Microscopy Measurement of
Extracellular Vesicles Derived from Plasma. Light Scattering Methods to
Characterize Extracellular Vesicles. Nanoparticle Tracking Analysis.
Microvesicle and Exosome Proteomic Analysis - Extracellular Vesicle
Proteomic Analysis. CLINICAL PERSPECTIVES. Microvesicles and Exosomes in
Cancer. Extracellular Vesicles and Tissue Factor. Extracellular Vesicles in
Normal Pregnancy and Pre-Eclampsia. Extracellular Vesicles in
Cardiovascular Disease. Extracellular Vesicles in Immunology.