Extracellular Vesicles in Human Health and Diseases (eBook, PDF)

Redaktion: Ghosh, Asit Ranjan

• Format: PDF

Produktbeschreibung

This book reviews the physiological and therapeutic applications of extracellular vesicles (EV) of different cell types. The initial chapter of the book focuses on their evolution, physiological functions, inter- and intra-cellular communication, and their strategic applications in defining different health disorders including aging, pathogenicity, toxicity, and drug delivery. The chapter also provides an overview of recent technologies for EV isolation, analysis, and quantification. The chapter also examines the role of EVs in viral and bacterial pathogenesis and discusses the emerging potential of EVs as diagnostic and therapeutic tools. It also discusses the emerging role of EVs including endosome-derived exosomes and fragments of the cellular plasma membrane in intercellular communication by transporting messenger RNA, microRNA (miRNA), and proteins. The book further explores the potential of membrane vesicles in the prevention, diagnosis, and treatment of inflammatory diseases, metabolic disorders, cardiovascular diseases, and neurodegenerative disorders. This book address researchers, clinicians, and doctoral and graduate students working in cellular molecular biology, cancer biology, infectious diseases, molecular medicine, biomedicine, neurobiology, microbiology, and translational medicine.

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Produktdetails

• Verlag: Springer Nature Singapore
• Seitenzahl: 329
• Erscheinungstermin: 1. August 2024
• Englisch
• ISBN-13: 9789819724949
• Artikelnr.: 71348953

Autorenporträt

Dr. Asit Ranjan Ghosh is a Professor (Higher Academic Grade) of the Department of Integrative Biology, School of BioSciences and Technology of Vellore Institute of Technology (VIT), Vellore since 2005. He has worked in the field of diarrheal and enteric infections since 1986 leading to Ph.D. with ICMR fellowships at the ICMR-National Institute of Cholera and Enteric Diseases, Kolkata (1986-1991) under the University of Calcutta, Kolkata with the understanding of pathogenic mechanisms and molecular epidemiology of major etiologies, for their better diagnosis to enhance the rate of recovery among hospitalized pediatric subjects, in community, related environmental intervention, vaccine development with experience in molecular microbiology and immunodiagnostics. He has earlier served as Scientist B and Scientist C in ICMR-Regional Medical Research Centre, Port Blair between 1994-2003; Visiting Research Associate at Johns Hopkins School of Hygiene and Public Health, Johns Hopkins University, Baltimore, USA (1991-1993); Visiting Professor & COE Researcher at Obihiro University of Agriculture and Veterinary Medicine,Obihiro, Japan (2003-2004); Assistant Director in Centre for Infectious Diseases and Control, VIT University (2010-2015). His recent focus of research is on Gut health infection, diagnosis, and control. Gastroenteritis is an event of infection but disease like irritable bowel syndrome is because of dysbiosis. In both cases, microbial populations, especially bacteria play a key role to maintain/ disturb homeostasis. Hence, host interaction with pathogens, commensals, and probiotics are the area of research to understand their common and special behavior and to find therapeutic solutions for the control of infection, inflammation, colon cancer, and obesity. He is a member of more than 10 national and international scientific bodies and a reviewer of several Scopus-indexed journals. He has more than 18 years of teaching experience inMicrobiology, Immunology, Immunotechnology, Cell Biology, Molecular Biology, Diagnostic Microbiology, Medical Biotechnology, Probiotics Technology, Food Nutrition, and Health. He has also published more than 120 research articles in peer-reviewed international journals and authored or co-authored 12 book chapters.      

Inhaltsangabe

Chapter 1_Historical Perspectives of Research Trends on Extracellular Vesicles.- Chapter 2_Methods in Extracellular Vesicle Isolation, Characterization, and Production.- Chapter 3_Therapeutic Prospects of Stem Cell-Derived EVs: Upcoming Avenues, Promises and Challenges.- Chapter 4_Extracellular Vesicles in Cell-Cell Communications and Potential in Clinical Interventions.- Chapter 5_Extracellular Vesicles and Bacterial Infection.- Chapter 6_Extracellular Vesicles and Bacterial Infections in Fish.- Chapter 7_Probiotics Associated Extracellular Vesicles in Health and Diseases.- Chapter 8_Extracellular Vesicles in Viral Infection.- Chapter 9_Revolutionizing Viral Vaccine Strategies: The Dual-Action Potential of Extracellular Vesicles in Efficient Antigen Delivery and Immune Response Amplification.- Chapter 10_Extracellular Vesicles and Inflammatory Diseases.- Chapter 11_Extracellular Vesicles in Cancer Diagnosis.- Chapter 12_Extracellular Vesicles and Cancer Therapy.- Chapter 13_Exploring Extracellular Vesicles as a Potential Source of Biomarkers for the Diagnosis of Colorectal Cancer and its Current Challenges.- Chapter 14_Extracellular Vesicles and Cardiovascular Disease: Diagnostic and Therapeutic Perspective.- Chapter 15_Therapeutic Role of Extracellular Vesicles in Neurodegenerative Disorders.- Chapter 16_The Role of Extracellular Vesicles in Aging: An Overview and Implications.