eBook, PDF

Extrasynaptic GABAA Receptors (eBook, PDF)

Beschreibung

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABAA receptors underlie classical "phasic" GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Technische Details

• Geräte: PC
• ohne Kopierschutz
• Größe: 7.63MB

Barrierefreiheit

• Text-to-Speech

Produktdetails

• Verlag: Springer US
• Seitenzahl: 295
• Erscheinungstermin: 22. September 2014
• Englisch
• ISBN-13: 9781493914265
• Artikelnr.: 43783228

Rezensionen

"This is an excellent monograph on the subject of GABA neurotransmission and GABA receptors in the synaptic and postsynaptic regions. ... I highly recommend this book for neuroscientists, and neurophysiologists in an academic setting. It is of use for students, fellows, and postdoctoral scholars." (Joseph J. Grenier, Amazon.com, May, 2015)