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Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and…mehr
Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. Updated material includes inflammation focusing in particular on chorioamnionitis and fetal brain injury; genetic brain injury; and expanded sections on cholestasis, diabetes, and thyroid disease. An updated, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.
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Inhaltsangabe
Part I. Epidemiology, Pathophysiology, and Pathogenesis of Fetal and Neonatal Brain Injury: 1. Neonatal encephalopathy: epidemiology and overview 2. Neuronal cell death mechanisms relevant to humans: rethinking modeling neonatal hypoxic-ischemic encephalopathy 3. Cellular and molecular biology of hypoxic-ischemic encephalopathy 4. The pathogenesis of preterm brain injury Part II. Pregnancy, Labor, and Delivery Complications Causing Brain Injury: 5. Prematurity and complications of labor and delivery 6. Risks and complications of multiple gestation 7. Intrauterine growth restriction 8. Maternal diseases that affect fetal and neonatal neurodevelopment 9. Obstetrical conditions and practices that affect the fetus and newborn 10. Fetal and neonatal injury as a consequence of maternal substance abuse 11. Hypertensive disorders of pregnancy 12. Complications of labour and delivery 13. Fetal responses to asphyxia 14. Antepartum evaluation of fetal well-being 15. Intrapartum evaluation of the fetus Part III. Diagnosis of the Infant with Brain Injury: 16. Clinical manifestations of hypoxic-ischemic encephalopathy 17. The use of EEG and aEEG in assessing the term and preterm brain 18. Neuroimaging in the evaluation of pattern and timing of fetal and neonatal brain abnormalities 19. Light-based assessment of the brain 20. Placental pathology and the etiology of fetal and neonatal brain injury 21. Timing perinatal hypoxic-ischemic brain injury Part IV. Specific Conditions Associated with Fetal and Neonatal Brain Injury: 22. Congenital malformations of the brain 23. Neurogenetic disorders of the brain 24. Hemorrhagic lesions of the central nervous system 25. Neonatal stroke 26. Neurodevelopmental consequences of neonatal hypoglycemia 27. Hyperbilirubinemia and kernicterus 28. Polycythemia and fetal-maternal bleeding 29. Hydrops fetalis 30. Bacterial sepsis in the neonate 31. Neonatal bacterial meningitis 32. Neurological sequelae of congenital and perinatal infections 33. Neurological complications of perinatal human immunodeficiency virus infection 34. Inborn errors of metabolism and single gene disorders with features of neonatal encephalopathy 35. Acidosis and alkalosis 36. Persistent pulmonary hypertension of the newborn 37. Pediatric cardiac surgery: relevance to fetal and neonatal brain injury 38. Neonatal resuscitation: immediate management 39. Improving performance, reducing error, and minimizing risk in the delivery room 40. Extended management following resuscitation 41. Endogenous and exogenous neuroprotective mechanisms after hypoxic-ischemic injury 42. Neonatal seizures: evaluation, treatment, and prognosis 43. Nutritional support of the asphyxiated infant 44. Early outcomes after extremely preterm birth 45. Cerebral palsy: advances in definition, classification, management and outcome 46. Neurodevelopmental and neurobehavioral outcomes of prematurity: cognition, language, academic skills, and behavioral and emotional profiles 47. Neurocognitive outcomes in term infants with neonatal encephalopathy 48. Neonatal neuroethics 49. Medicolegal issues in perinatal brain injury.
Part I. Epidemiology, Pathophysiology, and Pathogenesis of Fetal and Neonatal Brain Injury: 1. Neonatal encephalopathy: epidemiology and overview 2. Neuronal cell death mechanisms relevant to humans: rethinking modeling neonatal hypoxic-ischemic encephalopathy 3. Cellular and molecular biology of hypoxic-ischemic encephalopathy 4. The pathogenesis of preterm brain injury Part II. Pregnancy, Labor, and Delivery Complications Causing Brain Injury: 5. Prematurity and complications of labor and delivery 6. Risks and complications of multiple gestation 7. Intrauterine growth restriction 8. Maternal diseases that affect fetal and neonatal neurodevelopment 9. Obstetrical conditions and practices that affect the fetus and newborn 10. Fetal and neonatal injury as a consequence of maternal substance abuse 11. Hypertensive disorders of pregnancy 12. Complications of labour and delivery 13. Fetal responses to asphyxia 14. Antepartum evaluation of fetal well-being 15. Intrapartum evaluation of the fetus Part III. Diagnosis of the Infant with Brain Injury: 16. Clinical manifestations of hypoxic-ischemic encephalopathy 17. The use of EEG and aEEG in assessing the term and preterm brain 18. Neuroimaging in the evaluation of pattern and timing of fetal and neonatal brain abnormalities 19. Light-based assessment of the brain 20. Placental pathology and the etiology of fetal and neonatal brain injury 21. Timing perinatal hypoxic-ischemic brain injury Part IV. Specific Conditions Associated with Fetal and Neonatal Brain Injury: 22. Congenital malformations of the brain 23. Neurogenetic disorders of the brain 24. Hemorrhagic lesions of the central nervous system 25. Neonatal stroke 26. Neurodevelopmental consequences of neonatal hypoglycemia 27. Hyperbilirubinemia and kernicterus 28. Polycythemia and fetal-maternal bleeding 29. Hydrops fetalis 30. Bacterial sepsis in the neonate 31. Neonatal bacterial meningitis 32. Neurological sequelae of congenital and perinatal infections 33. Neurological complications of perinatal human immunodeficiency virus infection 34. Inborn errors of metabolism and single gene disorders with features of neonatal encephalopathy 35. Acidosis and alkalosis 36. Persistent pulmonary hypertension of the newborn 37. Pediatric cardiac surgery: relevance to fetal and neonatal brain injury 38. Neonatal resuscitation: immediate management 39. Improving performance, reducing error, and minimizing risk in the delivery room 40. Extended management following resuscitation 41. Endogenous and exogenous neuroprotective mechanisms after hypoxic-ischemic injury 42. Neonatal seizures: evaluation, treatment, and prognosis 43. Nutritional support of the asphyxiated infant 44. Early outcomes after extremely preterm birth 45. Cerebral palsy: advances in definition, classification, management and outcome 46. Neurodevelopmental and neurobehavioral outcomes of prematurity: cognition, language, academic skills, and behavioral and emotional profiles 47. Neurocognitive outcomes in term infants with neonatal encephalopathy 48. Neonatal neuroethics 49. Medicolegal issues in perinatal brain injury.
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