eBook, ePUB

Flavonoids and Anti-Aging (eBook, ePUB)

The Role of Transcription Factor Nuclear Erythroid 2-Related Factor2

Redaktion: Soliman, Karam F. A.; Pathak, Yashwant V.
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The nuclear factor erythroid 2-related factor 2 (Nrf2) was described as a master regulator of the cellular antioxidant response. Moreover, many critical biological functions linked to cell viability, metabolism, autophagy, inflammation, immunity, and differentiation have been attributed to Nrf2, which regulates over 600 genes. It is well known that oxidative stress, which Nrf2 can ameliorate, plays a key role in many pathologic processes such as aging, obesity, diabetes, cancer, and neurodegenerative diseases.Flavonoids, on the other hand, through their ability to activate and upregulate Nrf2,...

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