Fragment-Based Drug Discovery (eBook, ePUB)

Redaktion: Howard, Steven; Abell, Chris

• Format: ePub

Produktbeschreibung

Fragment-based drug discovery is a rapidly evolving area of research, which has recently seen new applications in areas such as epigenetics, GPCRs and the identification of novel allosteric binding pockets. The first fragment-derived drug was recently approved for the treatment of melanoma. It is hoped that this approval is just the beginning of the many drugs yet to be discovered using this fascinating technique.

This book is written from a Chemist's perspective and comprehensively assesses the impact of fragment-based drug discovery on a wide variety of areas of medicinal chemistry. It will prove to be an invaluable resource for medicinal chemists working in academia and industry, as well as anyone interested in novel drug discovery techniques.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 314
• Erscheinungstermin: 17. Juni 2015
• Englisch
• ISBN-13: 9781782625650
• Artikelnr.: 44762030

Inhaltsangabe

Different flavours of Fragments
Advances in SPR Technology
Applications of NMR in Fragment-Based Drug Discovery
Issues around Fragments as an Approach, including a Computational/in silico Perspectives on Fragment-Based Drug Discovery
Fragment-Based Drug Discovery of Kinase Inhibitors
Fragment-Based Discovery of Antibacterials
Strategies for Fragment-Based Lead Generation
Fragment-Based Approaches to Epigenetic Targets
Application of Fragment-Based Drug Discovery to GPCRs
Fragment-Based Drug Discovery applied to Protein-Protein Interactions
Probing Difficult Targets