From Melanocytes to Melanoma (eBook, PDF)

The Progression to Malignancy

• Format: PDF

Produktbeschreibung

Leading researchers and clinicians join forces to explain how malignant melanoma develops from its benign precursor cell type. The authors focus on the molecular mechanisms involved in melanogenesis, in the malignant transformation of melanocytes, and in the further progression of primary melanomas into invasive and metastatic melanomas. They also review recent advances in our understanding of the basic biology of melanocytes and the development, migration, and differentiation of melanoblasts into melanocytes. The book provides an up-to-date understanding of the progressive mechanisms of oncological development in malignant melanoma, a likely model of malignant progress for other types of cancer, and the ongoing development of novel therapeutics.

Produktdetails

• Verlag: Humana Press
• Erscheinungstermin: 5. November 2007
• Englisch
• ISBN-13: 9781592599943
• Artikelnr.: 37352203

Inhaltsangabe

Melanocyte Development and Function.- The Origin and Development of Neural Crest-Derived Melanocytes.- MITF.- MITF.- Melanocytes and the Transcription Factor Sox10.- Human Cutaneous Pigmentation.- Melanocyte Distribution and Function in Human Skin.- Melanocyte Transformation and Progression to Melanoma.- Altered Signal Transduction in Melanoma.- BRN2 in Melanocytic Cell Development, Differentiation, and Transformation.- The Dynamic Roles of Cell-Surface Receptors in Melanoma Development.- Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation.- Genetic Progression From Melanocyte to Malignant Melanoma.- The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma.- RB/E2F Regulation and Dual Activity in the Melanocytic System.- Melanoma Development and Pigment Cell Transformation.- The Biology and Genetics of Melanoma.- The Biology of Xeroderma Pigmentosum.- Divergent Pathways to Cutaneous Melanoma.- Pigmentation, DNA Repair, and Candidate Genes.- Low-Penetrance Genotypes, Pigmentation Phenotypes, and Melanoma Etiology.- The Biology of Melanoma Progression.- Optical Imaging Analysis of Atypical Nevi and Melanoma.- Proteomics Analysis of Melanoma Cell Lines and Cultured Melanocytes.- Primary Invasive Melanoma to Metastatic Melanoma.- Paradigm of Metastasis for Malignant Melanoma.- Repair of UV-Induced DNA Damage and Melanoma Risk.- High-Risk Factors for Melanoma Metastasis.- Role of Melanoma Inhibitory Activity in Early Development of Malignant Melanoma.- Role and Regulation of PAR-1 in Melanoma Progression.- Molecular Mechanisms of Melanoma Metastasis.- Overview of Tumor Progression in Melanoma.- The Plasticity of Melanoma Cells and Associated Clinical Implications.- The Clinical Use of Molecular Markers as Predictors of Disease Outcome and Response to Therapy in Malignant Melanoma.- The Role of DCT/TYRP2 in Resistance of Melanoma Cells to Drugs and Radiation.- How Melanoma Cells Evade Chemotherapy.- Apoptosis in Melanoma.- Role of Melanoma-Associated Antigens.- Host Responses to Melanoma.- Future Perspectives.

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Part I. Melanocyte Development and Function
The Origin and Development of Neural Crest-Derived Melanocytes
Debra L. Silver and William J. Pavan
MITF: A Matter of Life and Death for Developing Melanocytes
Heinz Arnheiter, Ling Hou, Minh-Thanh T. Nguyen, Keren Bismuth, Tamas Csermely, Hideki Murakami, Susan Skuntz, WenFang Liu, and Kapil Bharti
MITF: Critical Regulator of the Melanocyte Lineage
Erez Feige, Laura L. Poling, and David E. Fisher
Melanocytes and the Transcription Factor Sox10
Michael Wegner
Human Cutaneous Pigmentation: A Collaborative Act in the Skin, Directed by Paracrine, Autocrine, and Endocrine Factors and the Environment
Zalfa A. Abdel-Malek and Ana Luisa Kadekaro
Melanocyte Distribution and Function in Human Skin: Effects of Ultraviolet Radiation
Yuji Yamaguchi and Vincent J. Hearing
Part II. Melanocyte Transformation and Progression to Melanoma
Altered Signal Transduction in Melanoma
Pablo López Bergami, Anindita Bhoumik, and Ze'ev Ronai
BRN2 in Melanocytic Cell Development, Differentiation, and Transformation
Anthony L. Cook, Glen M. Boyle, J. Helen Leonard, Peter G. Parsons, and Richard A. Sturm
The Dynamic Roles of Cell-Surface Receptors in Melanoma Development
Dong Fang and Meenhard Herlyn
Familial Melanoma Genes, Melanocyte Immortalization, and Melanoma Initiation
Dorothy C. Bennett
Genetic Progression From Melanocyte to Malignant Melanoma
Boris C. Bastian
The Multiple Roles of the Oncogenic Protein SKI in Human Malignant Melanoma
Dahu Chen, Qiushi Lin, I. Saira Mian, Jon Reed, and Estela E. Medrano
RB/E2F Regulation and Dual Activity in the Melanocytic System
Ruth Halaban
Melanoma Development and Pigment Cell Transformation
Claudia Wellbrock
The Biology and Genetics of Melanoma
Norman E.Sharpless and Lynda Chin
The Biology of Xeroderma Pigmentosum: Insights Into the Role of Ultraviolet Light in the Development of Melanoma
James E. Cleaver
Divergent Pathways to Cutaneous Melanoma
David C. Whiteman and Adèle C. Green
Pigmentation, DNA Repair, and Candidate Genes: The Risk of Cutaneous Malignant Melanoma in a Mediterranean Population
Maria Teresa Landi
Low-Penetrance Genotypes, Pigmentation Phenotypes, and Melanoma Etiology
Peter A. Kanetsky and Timothy R. Rebbeck
The Biology of Melanoma Progression: From Melanocyte to Metastatic Seed
A. Neil Crowson, Cynthia Magro, and Martin C. Mihm, Jr.
Optical Imaging Analysis of Atypical Nevi and Melanoma
Amanda Pfaff Smith and Dorothea Becker
Proteomics Analysis of Melanoma Cell Lines and Cultured Melanocytes
Katheryn A. Resing and Natalie G. Ahn
Part III. Primary Invasive Melanoma to Metastatic Melanoma
Paradigm of Metastasis for Malignant Melanoma
Stanley P. L. Leong
Repair of UV-Induced DNA Damage and Melanoma Risk
Qingyi Wei
High-Risk Factors for Melanoma Metastasis
Neil A. Accortt and Seng-jaw Soong
Role of Melanoma Inhibitory Activity in Early Development of Malignant Melanoma
Anja-Katrin Bosserhoff
Role and Regulation of PAR-1 in Melanoma Progression
Carmen Tellez and Menashe Bar-Eli
Molecular Mechanisms of Melanoma Metastasis
Mohammed Kashani-Sabet
Overview of Tumor Progression in Melanoma
David E. Elder
The Plasticity of Melanoma Cells and Associated Clinical Implications
Mary J. C. Hendrix, Elisabeth A. Seftor, Angela R. Hess, and Richard E. B. Seftor
The Clinical Use of Molecular Markers as Predictors of Disease Outcome and Response to Therapy in Malignant Melanoma
Steve R. Martinez, Hiroya Takeuchi, Dave S. B. Hoon
The Role

Rezensionen

From the reviews:

"...this compendium of current thinking is recommended reading for anyone with an interest in pigmentation and cancer and a valuable resource for any library." -- Melanoma Research

"This book, the first of its kind on melanoma, details the current state of our knowledge ... . should be viewed as an important resource for understanding the broad field of melanocyte and melanoma biology. Newcomers to the field ... will find this book extremely useful. ... This book captures the tremendous progress made in the field ... . It is a valuable resource for biologists and basic scientists ... as well as for pathologists; dermatologists, surgeons, and medical oncologists ... ." -- Lynn M. Schuchter, The New England Journal of Medicine, March, 2007

"...captures the tremendous progress made in the field...will help to propel the field to new successes...a valuable resource for biologists and basic scientists interested in the biology of pigment cells as well as for pathologists, dermatologists, surgeons, and medical oncologists interested in the diagnosis and treatment of melanoma." -- New England Journal of Medicine

"The editors have compiled a highly prestigious group of authors, who are leaders in the field of melanocyte and melanoma research, to present a very comprehensive exposition of the current knowledge of melanocyte biology and melanoma. ... As a clinical researcher, I found ... it fascinating, yielding a tremendous appreciation for the meticulous and extensive work that has been done to date, some of which has and more of which will very likely provide leads to clinical interventions." -- Janice P. Dutcher, Medical Oncology, Vol. 23 (3), 2006

"An extremely detailed book on each of the various pathways, growth factors, and oncogenes affecting the melanocyte. This is a comprehensive review and ... physicians such as dermatologists, pathologists, and oncologists will find it helpful. It is very thorough in its presentation of cellular events ... . This book will serve primarily as a reference for basic scientists and biologists. Physician scientists will also use the book. Clinicians may find the book highly detailed, with more information then they require." -- Mary C. Martini, Doody's Review Service, July, 2006