Functional Molecules from Natural Sources (eBook, PDF)

Redaktion: Wrigley, Stephen K; Bedford, Colin; Nicholson, Neville; Thomas, Robert

• Format: PDF

Produktbeschreibung

Naturally-occurring compounds have been, and continue to be, an important source of new leads and of commercially successful products for various industrial sectors, notably pharmaceuticals and agrochemicals. The conference, Functional Molecules from Natural Sources, held at Magdalen College, Oxford, in July 2009 set out to highlight current trends, challenges and successes in the exploitation of natural products from microbial, plant and marine sources. Based on the proceedings of this conference, the main themes of this book are modern and emerging perspectives on natural product utilization and improved strategies for natural products exploitation. It provides case studies on important natural product leads (functional molecules) and their enhancement. These take account of new medical applications, and advances in the understanding and manipulation of natural product biosynthesis at the genetic level. Highlights include an authoritative review of the entire field of natural anticancer agents, (with an emphasis on those currently in clinical development); an account of the optimisation of the pleuromutilin antibiotic template for human use, and a comprehensive description of the research programme that resulted in the discovery of platensimycin. Aricles on biosynthesis include studies of the antibiotics of Streptomyces coelicolor A3(2), the anthrax siderophore petrobactin, and the modification of oxidation and glycosylation events in the biosynthesis of mithramycins. Written by leading industrial experts from each sector, the book offers a unique blend of industrial and academic perspectives. It summarizes new approaches to optimising the exploitation of naturally occurring compounds within the pharmaceutical, nutraceutical and agrochemicals industries. New approaches to optimising the exploitation of naturally occurring compounds (including the genetics of natural product biosynthesis), novel screening technologies and recent advances in characterization methods are also covered.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 244
• Erscheinungstermin: 26. November 2010
• Englisch
• ISBN-13: 9781849732079
• Artikelnr.: 44769123

Autorenporträt

Stephen K. Wrigley has worked in the field of industrial natural products discovery and development for twenty five years. He is currently Chief Technical Officer at Hypha Discovery Ltd., a company exploring basidiomycetes as a source of pharmaceutical lead compounds. He previously held managerial and scientific positions focusing on microbial products discovery at RecombinoGen, Ltd., Cubist Pharmaceuticals (UK) Ltd, TerraGen Discovery, Inc., Xenova Ltd. and Glaxo Group Research Ltd. after obtaining BSc and PhD degrees in chemistry at Imperial College, London. Robert Thomas has been involved in natural products research for over sixty years, completing his PhD on fungal metabolite structure elucidation in 1951 at the London School of Hygiene and Tropical Medicine. After working for the CSIRO in Australia and following postdoctoral studies in Canada and London, he joined the Squibb Institute for Medical Research in New Jersey. He subsequently held senior teaching positions at Imperial College, London and the University of Surrey and founded the plant product-based biotechnology company Biotics Ltd., based primarily at the University of Sussex. Professor Thomas was the chairman of the organising committee for Functional Molecules from Natural Sources and two previous natural products conferences organised by the RSC Biotechnology Group. Colin T. Bedford gained chemistry degrees from the Universities of Manchester and Glasgow and pursued postdoctoral research on the isolation, characterisation, biosynthesis and biomimetic synthesis of natural products at the Universities of Oxford, Sussex and British Columbia. He then joined Shell Research's Tunstall Laboratory undertaking research in chemical toxicology, where he progressed to Principal Scientist. He was then appointed to a senior lectureship at the University of Westminster pursuing research in natural product biosynthesis. Currently he is an Honorary Research Fellow at University College London. Following graduation with a London degree in physiology and chemistry, Neville Nicholson spent five years at the Chemical Defence Establishment at Porton Down before joining Beecham Pharmaceuticals. He remained with this company in its various forms for thirty years, participating in the elucidation of the biosynthetic pathway of the ?-lactamase inhibitor, clavulanic acid, and more recently specialising as a medicinal chemist with particular interests in small molecules of natural origin. He is now pursuing these interests as an Independent Scientist.

Inhaltsangabe

Antitumour Agents from Nature
From Natural Products to Medicinal Chemistry
New Approaches for Drug Discovery with Natural Products
Biosynthesis and Biosynthetic Engineering of Nonribosomal Lipopeptides
Why Natural Product Discovery Won't Meet the Requirements of Market-Driven Economics
Marine Natural Products
From the Seabed to the Hospital Bed
Development of Lantibiotics for Treatment of Nosocomial Infections
Imino Sugars: A Major New Group of Therapeutic Agents
Well, Naturally
Modifying Oxidation and Glycosylation Events in the Biosynthesis of Natural Product Anticancer Drugs û Challenges for Combinatorial Biosynthesis
Pleuromutilins: Antibiotic Optimisation for Human Therapeutic Use
Acetogenic Anthraquinones and Alkaloids - Online Structural Elucidation, Biosynthesis, Bioactivities and Total Synthesis
Finding New Antibacterials: Opening a Window on the Black Box of Natural Product Discovery
Potential Plant Natural Products for Management of Neglected Diseases
Chemical Diversity by Other Means: The Biosynthesis of Polyketide Drugs
Structural, Synthetic and Biosynthetic Studies on an 'Acyl Transferase-Less. Polyketide Antibiotic, Mupirocin
Switching on Defence Genes with Plant Secondary Metabolites
Natural Products as Leads for New and Innovative Crop Protection Chemicals