G Protein-Coupled Receptors (eBook, PDF)

Structure, Signaling, and Physiology
Redaktion: Siehler, Sandra

• Format: PDF

Produktbeschreibung

Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically -adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 30. September 2010
• Englisch
• ISBN-13: 9780511904363
• Artikelnr.: 38202256

Inhaltsangabe

Part I. Advances in GPCR Protein Research: 1. The evolution of the
repertoire and structure of G protein-coupled receptors Torsten Schoenberg,
Kristin Schroeck, Claudia Staeubert and Andreas Russ; 2. Functional studies
of isolated GPCR-G protein complexes in the membrane bilayer of lipoprotein
particles Adam J. Kuszak, Xiao Jie Yao, Sören G. F. Rasmussen, Brian K.
Kobilka and Roger K. Sunahara; Part II. Oligomerization of GPCRs: 3. GPCR-G
protein fusions: use in functional dimerization analysis Graeme Milligan;
4. Time-resolved FRET approaches to study GPCR complexes Jean Phillipe Pin,
Damien Maurell, Laetitia Comps-Agrar, Carine Monnier, Marie-Laure Rives,
Etienne Doumazane, Philippe Rondard, Thierry Durroux, Laurent Prézeau and
Erin Trinquet; 5. Signaling of dopamine receptor homo- and hetero-oligomers
Ahmed Hasbi, Brian F. O'Dowd and Susan R. George; 6. Functional
consequences of chemokine receptor dimerization Mario Mellado, Carlos
Martinez-A. and Jose Miguel Rodgriguez-Frade; Part III. GPCR Signaling
Features: 7. G protein functions identified using genetic mouse models
Stefan Offermanns; 8. Kinetics of GPCR, G protein and effector activation
Peter Hein; 9. RGS-RhoGEFs and other RGS multidomain proteins as effector
molecules in GPCR-dependent and GPCR-independent cell signaling José
Vázquez-Prado and J. Silvio Gutkind; 10. Adenylyl cyclase isoform-specific
signaling of GPCRs Karin F. K. Ejendal, Julie A. Przybyla and Val J. Watts;
11. G protein-independent and ß arrestin-dependent GPCR signaling Zhongzhen
Nie and Yehia Daaka; 12. Assays to read GPCR modulation and signaling Ralf
Heilker and Michael Wolff; Part IV. Ligand Pharmacology of GPCRs: 13.
Quantifying allosteric ligand-receptor interactions Ivan Toma Vranesic and
Daniel Hoyer; 14. 7TM Receptor functional selectivity Terry Kenakin; Part
V. Physiological Functions and Drug Targeting of GPCRs: 15. Beta adrenergic
receptors in cardiovascular and respiratory diseases Michele Ciccarelli, J.
Kurt Chuprun and Walter J. Koch; 16. Role of metabotropic glutamate
receptors in CNS disorders Richard M. O'Connor and John F. Cryan; 17. S1P
receptor agonists, a novel generation of immunosuppressants Rosa Lopez
Almagro, Gema Tarrason and Nuria Godessart; 18. Wnt/Frizzled receptor
signaling in osteoporosis Georges Rawadi.