Gamma-Hydroxybutyrate (eBook, ePUB)

Pharmacological and Functional Aspects
Redaktion: Tunnicliff, Godfrey; Cash, Christopher D.

• Format: ePub

Produktbeschreibung

Gamma-hydroxybutyrate (GHB) has come a long way since early experiments in animals where it was found to induce a sleep-like state and from its use in general anaesthesia in human subjects. It has been found to be a naturally-occurring compound in the brain, a metabolite of GABA, the emerging ubiquitous inhibitory neurotransmitter. This has opened up a completely new line of research in an effort to establish a function for GHB.
Gamma-Hydroxybutyrate: Pharmacological and Functional Aspects has brought together the combined expertise of many of the leading authorities on the biochemistry, physiology and pharmacology of GHB in the central nervous system. Each chapter is an in-depth review of the field and the book itself will appeal to all neurobiologists interested in neurotransmitter mechanisms, as well as to clinicians and other health-care workers interested in this fascinating chemical.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 268
• Erscheinungstermin: 1. August 2002
• Englisch
• ISBN-13: 9781134495849
• Artikelnr.: 57532622

Autorenporträt

Gadfrey Tunnicliff, Christopher D. Cash

Inhaltsangabe

Metabolism and Distribution of Gamma
Hydroxybutyrate in the Brain. The Gamma
hydroxybutyrate Receptor in the Brain. Part of the Pharmacological Actions of Gamma
hydroxybutyrate Are Mediated by GABAB Receptors. Membrane Transport of Gamma
hydroxybutyrate. Action of Gamma
hydroxybutyrate on Neuronal Excitability and Underlying Membrane Conductances. Regulation of Central Dopamine by Gamma
hydroxybutyrate. Effects of Gamma
hydroxybutyrate on Sleep. Gamma
hydroxybutyrate and Absence Seizure Activity. Behavioral Pharmacology of Gamma
hydroxybutyrate. Therapeutic Uses of Gamma
hydroxybutyrate. Abuse Potential and Toxicology of Gamma
hydroxybutyrate. 4
Hydroxybutyric Aciduria. Gamma
Hydroxybutyrate and Oxidative Stress. The Role of Gamma
hydroxybutyrate in Brain Function.