Gene Expression Profiling by Microarrays (eBook, PDF)

Clinical Implications
Redaktion: Hofmann, Wolf-Karsten

• Format: PDF

Produktbeschreibung

Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means to classify cancer and other diseases. Gene expression profiling can also be used to predict clinical outcome and response to specific therapeutic agents. This survey spans recent applications of microarrays in clinical medicine, covering malignant disease including acute leukaemias, lymphoid malignancies and breast cancer, together with diabetes and heart disease. Investigators in oncology, pharmacology and related clinical sciences, as well as basic scientists, will value this review of a promising new diagnostic and prognostic technology.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 22. Juni 2006
• Englisch
• ISBN-13: 9780511217838
• Artikelnr.: 38183495

Autorenporträt

Wolf-Karsten Hofmann, MD, PhD is Professor of Medicine in the Department of Hematology, Oncology and Transfusion Medicine, Charite - University Hospital, Berlin. For four successive years he received the Young Investigator Award of the American Society of Hematology, and in addition to his research publications has written many book chapters in haematology and oncology.

Inhaltsangabe

Preface Eckhard Thiel; 1. Introduction Wolf-Karsten Hofmann; 2. Technique
of microarrays: microarray platforms Sven de Vos; 3. Quantitative quality
control of microarray experiments: toward accurate gene expression
measurements Xujing Wang and Martin J. Hessner; 4. Statistical analysis of
gene expression data David A. Elashoff; 5. Genomic stratification in
patients with heart failure Tara A. Bullard, Frédérick Aguilar, Jennifer L.
Hall and Burns C. Blaxall; 6. Gene expression profiling for the diagnosis
of acute leukemias Torsten Haferlach, Alexander Kohlmann, Susanne
Schnittger, Claudia Schoch and Wolfgang Kern; 7. Gene expression profiling
can distinguish tumour subclasses of breast carcinomas Ingrid A. Hedenfalk;
8. Gene expression profiling in lymphoid malignancies Christof Burek, Elena
Hartmann, Zhengrong Mao, German Ott and Andreas Rosenwald; 9. MRNA
profiling of pancreatic beta cells: investigating mechanisms of diabetes
Leentje Van Lommel, Yves Moreau, Daniel Pipeleers, Jean-Christophe Jonas
and Frans Schuit; 10. Prediction of response and resistance to treatment by
gene expression profiling Philipp Kiewe and Wolf-Karsten Hofmann.