Gene Therapy of Cancer (eBook, ePUB)

Translational Approaches from Preclinical Studies to Clinical Implementation
Redaktion: Lattime, Edmund C.; Gerson MD, Stanton L.

• Format: ePub

Produktbeschreibung

Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive.

Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies.

In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response.

• Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches
• Presents in-depth description of targeting systems and treatment strategies
• Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 554
• Erscheinungstermin: 28. August 2013
• Englisch
• ISBN-13: 9780123946324
• Artikelnr.: 39513308

Inhaltsangabe

Introduction
Overview of Viral and Non-Viral Vector Technologies
DNA Integration for Monitoring Outcome in Gene Therapy
Multiple Treatment Cycles and Gene Therapy
RNA interference-based therapy for cancer
Targeted systemic delivery of therapeutic siRNA
Lentiviral-vector Common Integration Sites
Selective Replicating Adenovirus and Tumor Necrosis
Cancer Suicide Gene Therapy
Adenovirus-retrovirus Hybrid Vectors
Electroporation gene therapy
Biomaterials-based technologies for therapeutics and imaging
RNA Inhibition gene therapy
Monocytogenes-based DNA Delivery System
Toxin based Cancer Gene Therapy
Overview: Rationale use of oncolytic virus in clinical applications
Clinical development directions in oncolytic viral therapy
Selectively replicating herpes simplex viral vector
Oncolytic Vaccinia Virus for Cancer Therapy
Lister strain Vaccinia Virus
Modification of Mammalian Reoviruses
Systemic Delivery of Oncolytic adenoviruses
HIF-activated Oncolytic Adenoviruses
Overview of Immune Targets and Pathways
Overview of Gene Therapy with Gene-modified T Cells
Genetically Engineered (TCR) T cells for adoptive therapy
Viral-based Strategies for Combined Vaccine/microenvironment Modulation
Dendritic Cell Vaccines
Recombinant Poxvirus Vaccines
Provenge® and Genetic Fusion Vaccines
Lentivector Vaccines
In vivo Immune Gene Therapy of Solid Tumours
Chemotherapy Delivered after Viral Immunogene Therapy
Overview: selecting effective targets for gene therapy of cancer
Targeting Telomerase-expressing Cancer Cells
Adenovirus-mediated shRNAs
Adenovirus-mediated SOCS3 Gene Transfer
p53-based Cancer Therapy
Strategies for tumor-directed delivery of siRNA
Overview of Drug Resistance and Manipulation
Clinical Trials using LV P140KMGMT for Gliomas
Delivery of Liposome-mediated MGMT-siRNA
Cytidine Deaminase Gene Therapy for Recurrent Cancer
Tissue Specific Gene Therapy
Radiation Therapy
Overview of angiogenesis and target identification
Combination of Notch and Ephrin- targeted Therapy
Effects of sustained VEGF blockade on the tumor microenvironment
Clinical studies of Aflibercept (VEGF Trap)
Overview of Molecular Imaging Strategies Using Gene-based Vectors
NIS for Radio Gene Therapy
Genetically Engineered Salmonella
NIS Imaging in Cancer
Targeted systemic gene therapy and molecular imaging
Issues and Solutions in Moving Gene-therapy Approaches in Early Phase Trials
Safety and Innovation in Cancer Gene Therapy
Issues and Solutions in Moving Gene-therapy Approaches to Late-phase Trials
FDA Review Process for Cancer Gene Therapy