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Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a…mehr
Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.
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Alan Wright is Programme Leader of the MRC Human Genetics Unit in Edinburgh. Nicholas Hastie is Director of the MRC Human Genetics Unit in Edinburgh.
Inhaltsangabe
Part I. Introductory Principles: 1. Genes and their expression Dirk-Jan Kleinjan 2. Epigenetic modification of chromatin Donncha Dunican, Sari Pennings and Richard Meehan 3. Population genetics and disease Donald Conrad and Jonathan Pritchard 4. Mapping common disease genes Naomi Wray and Petter Visscher 5. Population diversity, genomes and disease Gianpiero Cavalleri and David Goldstein 6. Study design in mapping complex disease traits Harry Campbell and Igor Rudan 7. Diseases of protein misfolding Christopher Dobson 8. Aging and disease Thomas Perls 9. The MHC paradigm - genetic variation and complex disease Adrian Kelly and John Trowsdale 10. Lessons from single gene disorders Nicholas Hastie 11. Environment and disease A. J. McMichael and K. B. G. Dear 12. Contemporary ethico-legal issues in genetics Renate Gertz, Shawn Harmon and Geoffrey Pradella Part II. Common Medical Disorders: 13. Developmental disorders Stephen Robertson and Andrew Wilkie 14. Genes, environment and cancer Timothy Bishop 15. The polygenic basis of breast cancer Paul Pharoah and Bruce Ponder 16. TP53: a master gene in normal and tumour suppression Pierre Hainaut 17. Genetics of colorectal cancer Susan Farrington and Malcolm Dunlop 18. Genetics of autoimmune disease John Bell and Lars Fugger 19. Susceptibility to infectious diseases Andrew Walley and Adrian Hill 20. Inflammatory bowel diseases Jean-Pierre Hugot 21. Genetic anaemias W. G. Wood and D. R. Higgs 22. Genetics of chronic disease: obesity Sadaf Farooqi and Stephen O'Rahilly 23. Type 2 diabetes mellitus Mark McCarthy 24. Genetics of coronary heart disease Rossi Naoumova, Stuart Cook, Paul Cook and Timothy Aitman 25. Genetics of hypertension B. Keavney and M. Lathrop 26. Obstructive pulmonary disease Bipen Patel and David Lomas 27. Skeletal disorders Robert Colbert 28. The genetics of common skin diseases Jonathan Rees 29. Molecular genetics of Alzheimer disease and other adult-onset dementias Peter St George-Hyslop 30. Major psychiatric disorders in adult life Amanda Elkin, Sridevi Kalidindi, Kopal Tandon and Peter McGuffin 31. Speech and language disorders Gabrielle Barnby and Anthony Monaco 32. Common forms of visual handicap Alan Wright 33. Genetic and environmental influences on hearing impairment Karen Steel 34. Pharmacogenomics - clinical applications Gillian Smith and Roland Wolf.
Part I. Introductory Principles: 1. Genes and their expression Dirk-Jan Kleinjan 2. Epigenetic modification of chromatin Donncha Dunican, Sari Pennings and Richard Meehan 3. Population genetics and disease Donald Conrad and Jonathan Pritchard 4. Mapping common disease genes Naomi Wray and Petter Visscher 5. Population diversity, genomes and disease Gianpiero Cavalleri and David Goldstein 6. Study design in mapping complex disease traits Harry Campbell and Igor Rudan 7. Diseases of protein misfolding Christopher Dobson 8. Aging and disease Thomas Perls 9. The MHC paradigm - genetic variation and complex disease Adrian Kelly and John Trowsdale 10. Lessons from single gene disorders Nicholas Hastie 11. Environment and disease A. J. McMichael and K. B. G. Dear 12. Contemporary ethico-legal issues in genetics Renate Gertz, Shawn Harmon and Geoffrey Pradella Part II. Common Medical Disorders: 13. Developmental disorders Stephen Robertson and Andrew Wilkie 14. Genes, environment and cancer Timothy Bishop 15. The polygenic basis of breast cancer Paul Pharoah and Bruce Ponder 16. TP53: a master gene in normal and tumour suppression Pierre Hainaut 17. Genetics of colorectal cancer Susan Farrington and Malcolm Dunlop 18. Genetics of autoimmune disease John Bell and Lars Fugger 19. Susceptibility to infectious diseases Andrew Walley and Adrian Hill 20. Inflammatory bowel diseases Jean-Pierre Hugot 21. Genetic anaemias W. G. Wood and D. R. Higgs 22. Genetics of chronic disease: obesity Sadaf Farooqi and Stephen O'Rahilly 23. Type 2 diabetes mellitus Mark McCarthy 24. Genetics of coronary heart disease Rossi Naoumova, Stuart Cook, Paul Cook and Timothy Aitman 25. Genetics of hypertension B. Keavney and M. Lathrop 26. Obstructive pulmonary disease Bipen Patel and David Lomas 27. Skeletal disorders Robert Colbert 28. The genetics of common skin diseases Jonathan Rees 29. Molecular genetics of Alzheimer disease and other adult-onset dementias Peter St George-Hyslop 30. Major psychiatric disorders in adult life Amanda Elkin, Sridevi Kalidindi, Kopal Tandon and Peter McGuffin 31. Speech and language disorders Gabrielle Barnby and Anthony Monaco 32. Common forms of visual handicap Alan Wright 33. Genetic and environmental influences on hearing impairment Karen Steel 34. Pharmacogenomics - clinical applications Gillian Smith and Roland Wolf.
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