Nancy H. Colburn

Genes and Signal Transduction in Multistage Carcinogenesis (eBook, ePUB)

• Format: ePub

Produktbeschreibung

This book describes the identification and characterization of genetic loci that determine susceptibility to liver, mammary, or skin carcinogenesis in rodents. It focuses on protein kinases and phospholipases, and stress-related signal transduction.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 480
• Erscheinungstermin: 25. November 2020
• Englisch
• ISBN-13: 9781000147278
• Artikelnr.: 60507284

Autorenporträt

Nancy H. Colburn (Author)

Inhaltsangabe

Part I: Genetic Variants for Responses to Carcinogens, Tumor Promoters, and
Growth Factors 1. Genetic Control of Hepatocarcinogenesis in Inbred Mice 2.
Modulation of Mammary Carcinogenesis by Enhancer and Suppressor Genes 3.
Genetic Determinants of Susceptibility to Mouse Skin Tumor Promotion in
Inbred Mice 4. Suppression and Expression of the Transformed Phenotype in
Two-Stage C3H10T1/2 Transformants 5. Genetic Analysis of Transformation by
the src Oncogene 6. Transduction of Mitogenic Signals in Normal and
Malignant Cells Impaired in Na+ :H+ Antiport-Mediated pH Regulation Part
II: Genes That Confer Susceptibility to Neoplastic Transformation 7. Genes
and Signals Involved in Tumor Promoter-Induced Transformation 8. Regulation
of Gene Expression by the Tumor Promoter 12-0-Tetr adecanoylphorbol-13
-Acetate 9. Gene Activation During Multistage Carcinogenesis in Mouse Skin
10. Tumor Promotion by 2,3,7,8-Tetrachlorodibenzo-p-dioxin 11. Genes That
Confer Susceptibility to Neoplastic Transformation on Rat Fibroblasts 12.
Regulation of Human Papillomavirus Gene Expression Part III: Signal
Transduction: Protein Kinases and Phospholipases 13. Protein Kinase C:
Structural Definition 14. Role of Protein Kinase C in Stimulation of
Interleukin 2 Production 15. Lipocortins, a Family of Phospholipase
A2-Inhibitory Proteins 16. Role of rafand myc Oncogenes in Signal
Transduction Part IV: Stress-Associated Signals and Gene Regulation 17. fos
and the Immediate-Early Response in the Central Nervous System 18. Free
Radicals and Signal Transduction in Tumor Promotion 19. cis- and
trans-Acting Genetic Elements Responsible for Induction of Specific Genes
by Tumor Promoters, Serum Factors, and Stress 20. Structure Function
Analysis of fos Protein