Gundela Meyer

Genetic Control of Neuronal Migrations in Human Cortical Development (eBook, PDF)

• Format: PDF

Produktbeschreibung

The early steps in corticogenesis are decisive for the correct unfolding of neurogenesis, neuronal migration and differentiation under tight genetic control. In this monograph, the author outlines the main events in human preplate formation according to their timetable of appearance and the expression of developmentally relevant gene products. Also examined are the gradual transformation of the preplate into the cortical plate, and the establishment of the transient compartments of the foetal cortical wall.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 114
• Erscheinungstermin: 3. Februar 2007
• Englisch
• ISBN-13: 9783540366898
• Artikelnr.: 37368369

Autorenporträt

Gundela Meyer, Universidad de la Laguna, Tenerife, Canary Islands, Spain

Inhaltsangabe

Materials and Methods.- The Anatomical Basis of Human Cortical Development.- Neuronal Miqration.- Compartments of the Cortical Wall.- The Cortical Hem: Signaling Center and Birthplace of CR Cells.- The Reelin-Dab1 Signaling Pathway.- The Cdk5/p35 Pathway.- LIS1 and DCX: Key Genes for Neuronal Migration and Cortical Folding.- ARX Deficiency: A Novel Type of Lissencephaly.- Final Considerations: The Unique Features of Human Brain Development.