Wai Nang Choy

Genetic Toxicology and Cancer Risk Assessment (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!

This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.

Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!

Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment

reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis

calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens

reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models

discusses the threshold concept of carcinogenesis

demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens

considers structural activity relationship (SAR) analysis of chemical carcinogenicity

describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays

illustrates the use of genetic biomarkers for dosimetry analysis

and more!
Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Asse

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 406
• Erscheinungstermin: 31. August 2001
• Englisch
• ISBN-13: 9781135554200
• Artikelnr.: 58764212

Autorenporträt

Wai Nang Choy

Inhaltsangabe

Human Cancer Genetics Jason W. Barlow and David Malkin Genetic Toxicity
Tests for Predicting Carcinogenicity Errol Zeiger Genotoxic and
Nongenotoxic Mechanisms of Carcinogenesis Wai Nang Choy Structure-Activity
Relationship (SAR) and its Roles in Cancer Risk Assessment David Y. Lai and
Yin-tak Woo Regulatory Genetic Toxicology Tests Wai Nang Choy Complementary
Genetic Toxicology Assays B. Bhaskar Gollapudi The Mouse Lymphoma Assay
(MLA) Using the Microwell Method Masamitsu Honma and Toshio Sofuni The In
Vitro Micronucleus Assay Marilyn J. Aardema and Micheline Kirsch-Volders
ICH Guidelines on Genotoxicity and Carcinogenicity: Scientific Background
and Regulatory Practice Lutz Müller, Peter Kasper, and Leonard Schechtman
New OECD Genetic Toxicology Guidelines and Interpretation of Results
Michael C. Cimino Dose-Response Relationships in Chemical Carcinogenesis
and Cancer Risk Assessment Werner K. Lutz Molecular Epidemiology and
Biomarkers Jia-Sheng Wang, Jonathan M. Links, John Groopman Quantitative
Cancer Risk Assessment of Nongenotoxic Carcinogens Anna M. Fan and Robert
A. Howd Risk Assessment of Genotoxic Carcinogens Lauren Zeise Biologically
Based Cancer Risk Assessment Models Suresh H. Moolgavkar