Genetics of African Populations in Health and Disease (eBook, ePUB)

Redaktion: Ibrahim, Muntaser E.

• Format: ePub

Produktbeschreibung

The birthplace of modern humans, Africa, has the highest genetic diversity in the world, yet it remains vastly understudied. With biomedical research increasingly focused on human variation, studying the large population size and number of mutations in African genomes could unravel the complexity of phenotypic traits underlying the biology of our species and hold huge potential for scientific and medical advances. An initial chapter 'conceptualizes Africa', providing relevant terminology. The first section covers genetic history and population structure. The next section looks at the genetic basis of common infectious diseases, such as leishmaniasis, malaria and tuberculosis, with a final part considering common non-communicable diseases, such as diabetes, hypertension, obesity, heart disease and cancer. Gene environment interaction under globalization and the burden of diseases of lifestyle are included. For researchers and graduate students in biological anthropology, genetic anthropology, human and population genetics, and public health.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 19. Dezember 2019
• Englisch
• ISBN-13: 9781108657952
• Artikelnr.: 62742332

Inhaltsangabe

1. Reflections on conceptualizing Africa for biological studies with a historical component: a small essay Shomarka Omar Y. Keita; 2. History and genetics in Africa: multidisciplinary efforts Shomarka Omar Y. Keita and Muntaser E. Ibrahim; 3. Disease
selection
and evolution in the African landscape Muntaser Ibrahim and Endashaw Bekele; 4. Genetic susceptibility to visceral leishmaniasis Hiba S. Mohamed
Muntaser E. Ibrahim and Jenefer M. Blackwell; 5. Genetics of infection in Sub-Saharan Africa: what can the study of Mendelian immunodeficiency disorders contribute? Melanie Newport; 6. Pharmacogenomics and infectious diseases in Africa: an evolutionary perspective Jennifer L. Baker
Daniel Shriner
Amy R. Bentley and Charles N. Rotimi; 7. A glimpse into pharmacogenomics in Africa Collet Dandara and Alice Matimba; 8. Genomics of cardiometabolic disorders in Sub-Saharan Africa Sally N. Adebamowo
Fasil Tekola-Ayele
Adebowale A. Adeyemo and Charles N. Rotimi; 9. Breast cancer in African populations Konduru S. Sastry and Lotfi Chouchane; 10. Socio-biological transition and cancer: prospects for Africa Sulma Mahmoud
Khalid O. Alfarouk
Ahmed M. Elhassan
Kamal Hamad and Muntaser E. Ibrahim; 11. The genetic epidemiology of orphan diseases in North Africa Lilia Romdhane
Olfa Messaoud
Rym Kefi
Afaf Tiar
Ahlem Amouri
Mourad Mokni
Neji Tebib
Mohamed Zghal
Abdelhamid Barakat
Ahmed Houmeida
Mariem Bozguiya
Mohamed Othman
Ghada El Qameh and Sonia Abdelhak; 12. Birth defects and genetic disease in Sub-Saharan Africa Ambroise Wonkam; 13. Neurogenetic disorders in Africa: hereditary spastic paraplegia: a case study Liena E. O. Elsayed
Ammar E. M. Ahmed and Giovanni Stevanin.