Genetics of Autoimmunity (eBook, PDF)

Redaktion: Bock, Gregory R.; Goode, Jamie A.

• Format: PDF

Produktbeschreibung

This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated. Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title: * descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific * discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 260
• Erscheinungstermin: 1. September 2005
• Englisch
• ISBN-13: 9780470021385
• Artikelnr.: 37289704

Autorenporträt

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

Inhaltsangabe

Symposiumon Genomics of autoimmunity
held at the Novartis Foundation
London
22-24 June
2004. Editors: Gregory Bock (Organizer) and Jamie Goode. This symposium is based on a proposal by Abul Abbas
David Hafler and John Rioux. Abbul Abbas: Chair's introduction. Mark Daly: Patterns of genetic variation in humans and mice. Discussion. David B. Goldstein: Haplotype tagging in pharmacogenetics. Discussion. Simon J. Foote
Justin P. Rubio
Melanie Bahlo
Trevor J. Kilpatrick
Terence P. Speed
Jim Stankovich
Rachel Burfoot
Helmut Butzkueven
Laura Johnson
Chris Wilkinson
Bruce Taylor
Michele Sale
Ingrid A. F. van derMei
Joanne L. Dickinson and Patricia Groom: Multiple sclerosis: a haplotype association study. Discussion. Juha Kere: Mapping genes for asthma and psoriasis. Discussion. Linda S. Wicker
Carolyn L. Moule
Heather Fraser
Carlos Penha-Goncalves
Dan Rainbow
Valerie E. S. Garner
Giselle Chamberlain
Kara Hunter
Sarah Howlett
Jan Clark
Andrea Gonzalez-Munoz
Anne Marie Cumiskey
Paul Ti¡en
Joanna Howson
Barry Healy
Luc J. Smink
Amanda Kingsnorth
Paul A. Lyons
Simon Gregory
Jane Rogers
John A.Todd and Laurence B. Peterson: Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse . Discussion. Srividya Subramanian and Edward K. Wakeland: The importance of epistatic interactions in the development of autoimmunity. Discussion. Timothy J. Vyse
Angela Richardson
EmilyWalsh
Lisa Farwell
MarkJ. Daly
Cox Terhorst and John D. Rioux: Mapping autoimmune disease genes in humans: lessons from IBD and SLE. Discussion. Cisca Wijmenga and Martin C. Wapenaar: A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease. Discussion. Timothy W. Behrens
Robert R. Graham
Chieko Kyogoku
Emily C. Baechler
Paula S. Ramos
Clarence Gillett
Jason Bauer
Ward A. Ortmann
Keli L. Hippen
Erik Peterson
Carl D. Langefeld
Kathy L.Moser
Patrick M. Ga¡neyand Peter K. Gregersen: Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus. Discussion. Vigo Heissmeyer
Fernando Maciä n
Rajat Varma
Sin-Hyeog Im
Francisco García-Cozar
Heidi F.Horton
Michael C. Byrne
Stefan Feske
K. Venuprasad
Hua Gu
Yun-Cai Liu
Michael L. Dustin and Anjana Rao: A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signaling. Discussion. Adrian Liston and Christopher C. Goodnow: Genetic lesions in thymicTcell clonal deletion and thresholds for autoimmunity. Discussion. Lalitha Vijayakrishnan
Jacqueline M. Slavik
Zsolt Illés
Dan Rainbow
Laurence B. Peterson
Arlene S. Sharpe
Linda S. Wickerand
Vijay K. Kuchroo: An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in Tcells. Discussion. Adrian Ting
Stefan Lichtenthaler
Ramnik Xavier
Soon-Young Na
Shahrooz Rabizadeh
TaraHolmes and Brian Seed: Large-scale screens for cDNAs with in vivo activity. Discussion. Jenny Ting: Genomic mining of new genes and pathways in innate and adaptive Immunity. Discussion. Index of contributors. Subject index.