Genetics of Common Diseases (eBook, PDF)

Future Therapeutic and Diagnostic Possibilities
Redaktion: Day, Ian; Humphries, Steve

• Format: PDF

Produktbeschreibung

This is a collection of papers from the Fifth Annual Molecular Pathology Symposium on the 10 December 1996. They represent the contributions to that meeting made by a set of distinguished scientists and clinicians whose work pertains to the furtherment of our understanding of the genetic components of common diseases and potential future approaches

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 344
• Erscheinungstermin: 17. Dezember 2020
• Englisch
• ISBN-13: 9781000102277
• Artikelnr.: 60654330

Autorenporträt

Department of Medicine, University College London Medical School, The Rayne Institute, London, UK (address from October 1997: Wessex Human Genetics Institute, Southampton University Hospital, Southampton, UK). Department of Medicine, University College London Medical School, The Rayne Institute, London, UK.

Inhaltsangabe

Contributors
Abbreviations
Preface
1 Perspectives in human linkage studies. /S. Povey
Pairwise linkage analysis of Mendelian traits
Finding the cause of a disease which shows clear Mendelian inheritance
After a LOO score of +3, what next?
Narrowing the search by searching for critical recombinants
Linkage disequilibrium
Linkage analysis in more complex situations
Linkage in complex traits
Why are we doing this?
References
2 Twin research: nature versus nurture in common diseases. /K.O. Kyvik
Introduction
History
Biology of twinning
Demography
Twin studies
Assumptions
T he concept of concordance rates
Heritability
Twin studies and common diseases
Other types of twin studies
Conclusion
References
3 The molecular basis of genetic variation: mutation detection methodologies and limitations. /E. Spanakis and I.N.M. Day
Introduction
Current theories of mutation
Parallel development of theory with methodology
Methods of mutation detection
Limitations of current methods for mutation detection
Our approaches
Conclusions
References
4 Finding susceptibility genes for schizophrenia. /M.J. Owen and M.C. O'Donovan
Introduction
Molecular genetic approaches to schizophrenia
Candidate gene association studies
Conclusions
References
5 Approaches to determining the genetic basis of noninsulin
dependent diabetes mellitus. /M. McCarthy
Non
insulin
dependent diabetes mellitus (NIDDM)
Overview of approaches to dissect NIDDM
Choosing a candidate gene
Exploring candidate genes
Assessing genotype
phenotype correlations
Understanding the biology of complex traits
References
6 Population
scale genotype assays: APOE gene in Alzheimer's dementia and coronary risk. /I.N.M. Day, D. Palamand and E. Spanakis
Introduction: availability of population
scale gene testing
Background
Some future possibilities
References
7 Genetic tests for corona