Genome Editing for Neurodegenerative Diseases (eBook, ePUB)

From Concept to Clinical Trials
Redaktion: Singh in Biotechnology, Sandeep Kumar; Perry, George; Poeggeler, Burkhard; Yadav, Amarish Kumar

• Format: ePub

Produktbeschreibung

Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases. - Covers basic mechanisms of genome-editing tools and their therapeutic potential - Highlights current research progress and therapeutic strategies to use genome-editing tools against neurodegenerative diseases - Includes research on genome-editing tool development, from basic concept to clinical trials

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 400
• Erscheinungstermin: 17. Oktober 2024
• Englisch
• ISBN-13: 9780443238277
• Artikelnr.: 72240540

Inhaltsangabe

Introduction Burkhard Poeggeler 1. Therapeutic potential of genome editing tools in neurodegenerative diseases Ankur Kumar
Nandigam Pardhipa
Sachin G. Swami
Vibha Dwivedi and Anand K. Singh 2. Genetic and molecular basis of neurodegenerative diseases Sunanda Yogi
Anjali Sangeeth
Anuradha Venkatakrishnan Chimata
Radhika Padma and Amit Singh 3. Genome editing tools: principles
structures
and mechanisms Rayees Ahmad Naik
Mehak Naseer Mir
Roshni Rajpoot
Sonalika Singh
Kusum Singh and Sandeep Kumar Singh 4. Advances in CRISPER/Cas system and genome editing technologies for the treatment of neurodegenerative diseases Shailendra Kumar Mishra
Hung-Ming Chang
Ahmad A. Obaid and Sandeep Kumar Singh 5. Use of CRISPR system in genetic screening to detect neurodegenerative disease Koyel Kar 6. Epigenetic manipulation and gene regulation using the CRISPR/Cas system for neurodegenerative diseases Josephine Esposto 7. Transgene delivery system: viral
nonviral
and other methods for central nervous system Bhupender Sahu
Bibhudendu Behera and Umesh Kumar 8. Gene therapies for neurodegenerative disease: current knowledge and challenges Bhumi Arora
Sakshi Garg
Aditya Shrivastav
Mrinalini Sharma
Bhupender Sahu and Umesh Kumar 9. Gene therapy under clinical trials for neurodegenerative diseases Bhupender Sahu
Lakshita Tyagi
Prshant Tyagi and Umesh Kumar 10. Clinical challenges and future prospective in use of gene-editing tools as neurotherapeutics Burkhard Poeggeler