Genomic Surveillance and Pandemic Preparedness (eBook, ePUB)

Redaktion: Pandey, Rajesh

• Format: ePub

Produktbeschreibung

Genomic Surveillance and Pandemic Preparedness offers practical, in-depth instruction in where, how, and why genomic surveillance may be applied. Drawing heavily from the learnings during the COVID-19 pandemic, this book covers different aspects of microbes with a focus on viral genome sequencing and analysis, implementation and inference of genomic surveillance, and global data sharing best practices for future pandemic preparedness. Here, more than a dozen international authors consider host and pathogen genome interaction, population-level prevalence, individual disease susceptibility and gene protection, pathogen mutation evolutionary dynamics, RNA modulation of infection, pathogen diversity, and the role of coinfections and comorbidities in disease severity. A wide range of examples, from bacterial pathogens to fungal and viral infections, with an emphasis on recent COVID-19 analysis, are discussed. Finally, the authors provide step-by-step instruction in experimental and computational approaches for genomic surveillance, including nucleic acid isolation, sequencing library preparation, functional sequencing analysis, and bioinformatics pipelines. Throughout this book, importance is placed on inference-moving from genomic sequencing to meaningful genomic surveillance that bolsters pandemic preparedness.

• Highlights different aspects of genomic surveillance, from theory to implementation to inferences
• Covers a broad range of infectious diseases, with emphasis on recent COVID-19 studies
• Shares methods and approaches for sequencing-based pathogen detection, diagnostics, and surveillance
• Facilitates international collaboration in drug and vaccine development

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 450
• Erscheinungstermin: 29. Juni 2023
• Englisch
• ISBN-13: 9780443187681
• Artikelnr.: 68345439

Inhaltsangabe

Section A: Pathogens and Host: Genomics perspective 1. Population level
differences in COVID-19 prevalence, severity, and clinical outcome 2. Host
genetics in disease susceptibility and protection 3. RNA as modulators
infection outcome: Potential usage for genomic surveillance Section B:
Pathogen Diversity 4. Genomic surveillance of bacterial pathogens:
expanding horizons Section C: Cofactors in addition to pathogen 5. Host
immune responses in COVID-19: implication for preexisting chronic systemic
inflammation 6. Role of co-infections in modulating disease severities and
clinical phenotypes 7. Wastewater surveillance: a quick guide to check
community health Section D: Future pandemic preparedness 8. Experimental
repertoire to elucidate the functional landscape of hostepathogen
interactome 9. Computational means to understand and elucidate
hostepathogen interaction and outcome 10. Genomic surveillance system and
technologies Section E: Roadmap ahead 11. Interactions shaping the
Interactome: genome surveillance inclusive of host-pathogen 12. Health
informatics and data science for pandemic preparedness 13. Harsh
environmental stressors of high altitude on pathogens susceptibility 14.
Implications of antibiotics and antimicrobial resistance development during
COVID-19: questing genomic surveillance for a balancing act