Glycoscience: Chemistry and Chemical Biology I-III (eBook, PDF)

Redaktion: Fraser-Reid, Bertram O.; Thiem, Joachim; Tatsuta, Kuniaki

• Format: PDF

Produktbeschreibung

Glycoscience has become a term covering all sorts of activities and applications within or at the edge of carbohydrate research. Glycostructures play a highly diverse and crucial role in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them, but many facts still remain undiscovered. "All roads lead to carbohydrates ... we cannot do without them." (K.C. Nicolaou). Presently the field is experiencing a "quantum jump". Therefore the editors have drawn together in this three volume set plus an accompanying CD-ROM, the complete and up-to-date information on glycostructures, their chemistry and chemical biology, and present them in the form of a comprehensive and strictly systematic survey. Methodology oriented introductory chapters are followed by a homogeneous and systematic approach (occurrence, properties, synthesis, biosynthesis and degradation, chemical biology and medicine) arranged according to classes of glycostructures. The texts are furnished by 2.670 figures, chemical structures and reaction schemes (including more than 12.000 individual chemical reactions), and more than 9.000 references. The stimulating and readily accessible volumes of Glycoscience - Chemistry and Chemical Biology have been designed as the essential resource for both the experts in the field and the large community of investigators in fields like biomedicine, cancer research, pharmaceutical and biochemistry, biology, food science, agriculture or (bio-)engineering.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 2872
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642568749
• Artikelnr.: 53388463

Inhaltsangabe

Volume I.- 1 General Principles.- 1.1 Structure and Conformation of Carbohydrates.- 1.2 Properties of Carbohydrates.- 1.3 Separation and Purification of Carbohydrates.- 1.4 General Occurrence of Carbohydrates.- 2 General Synthetic Methods: Reactions at Non Anomeric Positions.- 2.1 Reactions at Oxygen Atoms.- 2.2 Oxidation and Reduction.- 2.3 Deoxygenation.- 2.4 Heteroatom Exchange.- 2.5 Anhydrosugars.- 2.6 C-C Bond Formation.- 2.7 C=C Bond Formation.- 2.8 Degradation Reactions.- 2.9 Rearrangement Reactions.- 3 General Synthetic Methods: Reactions at the Anomeric Center.- 3.1 Reactions at Oxygen Atoms.- 3.2 Oxidation, Reduction and Deoxygenation.- 3.3 Heteroatom Exchange: Glycosylation.- 3.3.1 Mechanistic Aspects.- 3.3.2 Glycosides as Donors.- 3.3.3 Glycosyl Halides and Anomeric Esters as Donors.- 3.4 Anomeric Anhydro Sugars.- 3.5 S-Glycosylation.- 3.6 N-Glycosylation.- 3.7 C-Glycosylation.- 3.8 Formation and Reactions of Glycal Derivatives.- 3.9 Degradation and Rearrangement Reactions.- Volume II.- 4 Monosaccharides.- 4.1 Occurrence and Significance.- 4.2 Properties.- 4.3 Synthesis of Biologically Relevant Monosaccharides.- 4.4 De Novo Synthesis of Monosaccharides.- 4.5 Formation of Complex Natural Compounds from Monosaccharides.- 4.6 Biosynthesis and Degradation.- 4.7 Chemical Biology and Biomedicine.- 5 Oligosaccharides.- 5.1 Occurrence and Significance.- 5.2 Properties.- 5.3 Synthesis.- 5.3.1 Enzymatic Glycosylation.- 5.3.2 Glycosyl Halides in Oligosaccharide Synthesis.- 5.3.3 Regio-and Stereoselective Methods of Glycosylation.- 5.3.4 Stereoselective Synthesis of ß-manno Glycosides.- 5.3.5 Combinatorial and Solid Phase Methods in Oligosaccharide Synthesis.- 5.4 Biosynthesis and Degradation of Galactosyloligosaccharides .....- 5.5 Chemical Biology and Biomedicine.- 5.5.1 Glycosylphosphatidylinositols.- 5.5.2 Mammalian Carbohydrate-Lectin Interactions.- 5.5.3 Multivalency in Protein-Carbohydrate Recognition.- Volume III.- 6 Complex Polysaccharides.- 6.1 Occurrenceand Significance.- 6.2 Properties.- 6.3 Synthesis of Sulfated Glycosaminoglycans.- 6.4 Biosynthesis and Degradation.- 6.5 Chemical Biology and Biomedicine.- 6.5.1 General Aspects.- 6.5.2 Mycobacterial Cell Wall Components.- 7 Glycolipids.- 7.1 Occurrence and Significance.- 7.2 Properties.- 7.3 Synthesis.- 7.4 Biosynthesis and Degradation.- 7.5 Chemical Biology and Biomedicine: Glycolipids and Glycosphingolipids.- 8 Glycoproteins.- 8.1 Occurrence and Significance.- 8.2 Properties.- 8.3 Synthesis and Applications of Biologically Relevant Glycopeptides.- 8.4 Chemical Biology and Biomedicine: Enkephalin-Derived Glycopeptide Analgesics.- 9 Other Glycoconjugates.- 9.1 Antitumor and Antimicrobial Glycoconjugates.- 9.2 Synthesis of Enediyne Antibiotic Oligosaccharides.- 9.3 Chemical Biology and Biomedicine of Glycosylated Natural Compounds.- 10 Glycomimetics.- 10.1 Introduction.- 10.2 Azaglycomimetics: Synthesis and Chemical Biology.- 10.3 Carbasugars: Synthesis and Functions.- 10.4 Sulfur Containing Glycomimetics.- 10.5 C-Glycosyl Analogs of Oligosaccharides and Glycosyl Amino Acids.- 10.6 Non-Sugar Glycomimetics.- IUPAC's 1996 Recommendations on Nomenclature of Carbohydrates.

Rezensionen

From the reviews:

"This set is certainly the most comprehensive to date in the fields of carbohydrate chemistry and chemical biology. The strength of this resource are in the range of topics covered, the well-organized and detailed presentations, and the selection of contributing authors, all of whom are experts ... . The usefulness of this set is further enhanced by the inclusion of a CD-ROM containing all three volumes. ... Overall, the set will be a useful reference for seasoned veterans as well as novices in carbohydrate research." (Hung-wen Liu, Journal of the American Chemical Society, Vol. 125 (3), 2003)

"These three volumes provide, in a useful and pleasing format, an impressively comprehensive and up-to-date overview of the chemistry and chemical biology of carbohydrates. They help the reader to access the accumulated knowledge from over 120 years of research in this area, in a form that nonspecialists too will find useful. A CD-ROM is also available to facilitate searching in the work." (Till Opatz and Horst Kunz, Angewandte Chemie, Vol. 42 (1), 2003)