GPCRs: From Deorphanization to Lead Structure Identification (eBook, PDF)

Redaktion: Bourne, H.; Michel, H.; Kuhnke, J.; Horuk, Richard

• Format: PDF

Produktbeschreibung

This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based on the international workshop GPCRs: From Deorphanisation to Lead Structure Identification, held in Berlin in May 2006.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 269
• Erscheinungstermin: 23. Mai 2007
• Englisch
• ISBN-13: 9783540489825
• Artikelnr.: 37367191

Inhaltsangabe

G-Proteins and GPCRs: From the Beginning.- Modeling GPCRs.- QSAR Modeling of GPCR Ligands: Methodologies and Examples of Applications.- Privileged Structures in GPCRs.- Designing Compound Libraries Targeting GPCRs.- Orphan Seven Transmembrane Receptor Screening.- The Role of GPCR Dimerisation/Oligomerisation in Receptor Signalling.- Deorphanization of G-Protein-Coupled Receptors.- Virus-Encoded G-Protein-Coupled Receptors: Constitutively Active (Dys)Regulators of Cell Function and Their Potential as Drug Target.- Modulation of GPCR Conformationsby Ligands, G-Proteins, and Arrestins.- High Content Screening to Monitor G Protein-Coupled Receptor Internalisation.- High-Throughput Lead Finding and Optimisation for GPCR Targets.