Green Chemistry Strategies for Drug Discovery (eBook, PDF)

Redaktion: Peterson, Emily A.; Manley, Julie B.

• Format: PDF

Produktbeschreibung

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate.

Written by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment.
The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included.

This book serves as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

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Produktdetails

• Verlag: RSC
• Seitenzahl: 322
• Erscheinungstermin: 11. Juni 2015
• Englisch
• ISBN-13: 9781782622659
• Artikelnr.: 44767734

Autorenporträt

Emily A. Peterson is a Senior Scientist in Medicinal Chemistry at Amgen. Emily received her Ph. D. in Organic Chemistry from University of California-Irvine with Larry E. Overman, accomplishing the total synthesis of biologically interesting alkaloid natural products and their analogues. She then conducted postdoctoral studies in asymmetric organocatalysis at Harvard University in the labs of Eric N. Jacobsen. Her research in Medicinal Chemistry has been primarily in the areas of oncology, schizophrenia and neuropathic pain. In addition to her drug discovery efforts, she has led the Green Chemistry Team at the Amgen Cambridge Site since 2009 and is a member of the American Chemical Society's Green Chemistry Institute Medicinal Chemistry Round Table.

Inhaltsangabe

Introduction: The Five Ws of Pharmaceutical Green Chemistry
Barriers to Adopting Green Chemistry in Drug Discovery
Toward a Green Laboratory: One Reaction at a Time
Greener Solvent Usage for
Discovery Chemistry Analysis and Purification
Green Chemistry and High Throughput Screening
Continuous Processing in Drug Discovery
Applying Green Chemistry Principles in Biologics Drug Development
Recycling and Reuse in the Laboratory
The Need for a Green Electronic Lab Notebook
Toxicology for Chemical Safety and Sustainability
Environmental Regulations and the Green Chemist
Patent Protection and Green Chemistry Innovation
The Business Case for Green Chemistry in Drug Discovery