Growth Factors and Psychiatric Disorders (eBook, PDF)

Redaktion: Chadwick, Derek J.; Goode, Jamie A.

• Format: PDF

Produktbeschreibung

The recent identification of susceptibility genes for schizophrenia, depression and learning and memory dysfunction suggest that psychiatric disorders may be influenced by a small number of genes with multiple actions. This is the first book to investigate the role of growth factors in these disorders, which should provide clues to the underlying biochemical mechanisms. For example, recent studies have substantiated the provocative finding that neuregulin 1 (NRG1)is a candidate gene for schizophrenia. Neuregulin and its receptors, the ErbB tyrosine kinases, are essential for development of the cardiovascular and nervous systems. Lack of NRG1 function may be involved in dysregulation of synaptogenesis and synaptic plasticity in the adult mediated through glutamate receptor function. Polymorphisms for BDNF (brain-derived neurotrophic factor) have also been implicated in the pathogenesis of schizophrenia. BDNF is a prevalent neurotrophic factor that plays an important role in the pathophysiology of depression, bipolar disease and other psychiatric disorders. Other topics addressed in this book include neuroplasticity and neurotrophic factors, signal transduction by neurotrophins, intracellular trafficking of growth factors, trophic factors and cognitive functions, neurotrophins and depression, and pharmacological treatments of schizophrenia.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 258
• Erscheinungstermin: 2. August 2008
• Englisch
• ISBN-13: 9780470751268
• Artikelnr.: 38198454

Autorenporträt

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: MOSES V CHAO, Skirball Institute of Biomolecular Medicine, New York, USA

Inhaltsangabe

Symposium on Growth factors and psychiatric disorders, held at the Novartis
Foundation, London, 20-22 March 2007.
Editors: Derek J. Chadwick (Organizer) and Jamie Goode.
This symposium is based on a proposal made by Moses Chao.
Moses Chao Chair's introduction.
Daniel C. Javitt Phenomenology, aetiology and treatment of  schizophrenia.
Discussion.
Jonathan Flint, Sagiv Shifman, Marcus Munafo and Richard Mott Genetic
variants in major depression.
Discussion.
Eero Castrén and Tomi Rantamäki Neurotrophins in depression and
antidepressant effects.
Discussion.
Jinbo Fan and Pamela Sklar Genetics of bipolar disorder: focus on BDNF
Val66Met polymorphism.
Discussion.
David A. Talmage Mechanisms of neuregulin action.
Discussion.
General discussion I.
H. Akil, S. J. Evans, C. A. Turner, J. Perez, R. M. Myers, W. E. Bunney,
E. G. Jones, S. J. Watson and other members of the Pritzker Consortium The
fibroblast growth factor family and mood disorders.
Discussion.
Jay N. Giedd, Rhoshel K. Lenroot, Philip Shaw, Francois Lalonde, Mark
Celano, Samantha White, Julia Tossell, Anjene Addington and Nitin Gogtay
Trajectories of anatomic brain development as a phenotype.
Discussion.
Bai Lu and Keri Martinowich Cell biology of BDNF and its relevance to
schizophrenia.
Discussion.
Enrico Tongiorgi and Gabriele Baj Functions and mechanisms of BDNF mRNA
trafficking.
Discussion.
Amar Sahay and René Hen Hippocampal neurogenesis and depression.
Discussion.
Andrés Buonanno, Oh-Bin Kwon, Leqin Yan, Carmen Gonzalez, Marines Longart,
Dax Hoffman and Detlef Vullhorst Neuregulins and neuronal plasticity:
possible relevance in schizophrenia.
Discussion.
Zhe-Yu Chen, Kevin Bath, Bruce McEwen, Barbara Hempstead and Francis Lee
Impact of genetic variant BDNF (Val66Met) on brain structure and function.
Discussion.
General discussion II.
D. Malaspina, M. Perrin, K. R. Kleinhaus, M. Opler and S. Harlap Growth and
schizophrenia: aetiology, epidemiology and epigenetics.
Discussion.
Luiz M. Camargo, Qi Wang and Nicholas J. Brandon What can we learn from the
disrupted in schizophrenia 1 interactome: lessons for target identification
and disease biology?
Discussion.
Michael Spedding and Pierre Gressens Neurotrophins and cytokines in
neuronal plasticity.
Discussion.
Moses Chao Closing remarks.
Index of contributors.
Subject index.