Handbook of Epigenetics (eBook, ePUB)

The New Molecular and Medical Genetics
Redaktion: O. Tollefsbol, Trygve

• Format: ePub

Produktbeschreibung

Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses.

In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.

• Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics
• Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine
• Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout
• Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction
• Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 918
• Erscheinungstermin: 8. September 2022
• Englisch
• ISBN-13: 9780323919500
• Artikelnr.: 65685547

Inhaltsangabe

1. Epigenetics Overview
SECTION I: Molecular Mechanisms of Epigenetics 2. Mechanisms of DNA
Methylation and Demethylation during Mammalian Development 3. Mechanisms of
Histone Modification 4. The Epigenetics of Non-coding RNA 5. Prions and
Prion-like Phenomena in Epigenetic Inheritance 6. Higher-order Chromatin
Organization in Diseases 7. Polycomb-group Proteins and Epigenetic Control
of Gene Activity
SECTION II: Methods in Epigenetics 8. Methods for Assessing DNA Cytosine
Modifications Genome-wide 9. Analyses of Genome-wide Histone Modifications
in the Mammalian Genome 10. Techniques for Genome-wide Expression of
Non-coding RNA 11. Computational Epigenetics
SECTION III: Model Organisms of Epigenetics 12. Epigenetics of Lower
Organisms 13. Drosophila Epigenetics 14. Models of Mouse Epigenetic
Inheritance: Classification, Mechanisms, and Experimental Strategies 15.
Plant Epigenomics
SECTION IV: Factors Influencing Epigenetic Changes 16. Dynamic Changes in
Epigenetic Modifications During Mammalian Transitions 17. Epigenetic
Biomarkers 18. Transposable elements shaping the epigenome  19. Metabolic
Regulation of DNA Methylation in Mammalian Cells 20. Dietary and Metabolic
Compounds Affecting Covalent Histone Modifications 21. Epigenetics, Stem
Cells and Cellular Differentiation 22. Regeneration Epigenetics 23.
Epigenetics of X-chromosome Inactivation 24. Epigenetics of Memory
Processes 25. Transgenerational Epigenetics 26. DNA Methylation Clocks in
Age-related Disease
SECTION V: Evolutionary Epigenetics 27. Evolution of Epigenetic Mechanisms
in Plants 28. Evolution of Epigenetic Mechanisms in Animals and Their Role
in Speciation    29. Adaptive Evolution and Epigenetics
SECTION VI: Epigenetic Epidemiology 30. Epigenetics of Livestock Breeding
31. Nutritional Epigenetics and Metabolic Syndrome 32. Epigenetics of Drug
Addiction 33. Environmental Influence of Epigenetics 34. The Gut Microbiota
Influence on Human Epigenetics, Health and Disease 35. Population
Pharmacoepigenomics
SECTION VII: Epigenetics and Human Disease 36. Cancer Epigenetics 37. The
Role of Epigenetics in Autoimmune Disorders 38. Epigenetics of Brain
Disorders 39. The Epigenetics of Metabolic Diseases 40. Imprinting
Disorders in Humans
SECTION VIII: Epigenetic Therapy 41. DNA Demethylating Agents in Clinical
Medicine 42. Clinical Applications of Histone Deacetylase Inhibitors 43.
Combination Epigenetic Therapy
SECTION XI: The Future of Epigenetics 44. New Directions for Epigenetic
Research: Application of Engineered DNA-binding Molecules to Locus-specific
Epigenetic Research