Gary S. Silverman, Philip E. Rakita

Handbook of Grignard Reagents (eBook, ePUB)

• Format: ePub

Produktbeschreibung

This handbook provides the theoretical and practical information necessary to explore new applications for Grignard reagents on a day-to-day basis, presenting a comprehensive overview of current research activities in Grignard chemistry. This book surveys specific reactions and applications of Grignard reagents, organized by type of substrate and the general category of reaction. It also summarizes the spectrum of reactions exhibited by Grignard reagents.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Erscheinungstermin: 25. April 1996
• Englisch
• ISBN-13: 9781040214152
• Artikelnr.: 73255872

Autorenporträt

Gary S. Silverman, Philip E. Rakita

Inhaltsangabe

Part 1 Methods of Grignard reagent preparation: common method of Grignard
reagent preparation; preparation of Grignard reagents from olefins and
acetylenes; magnesium activation. Part 2 Safe handling practices: safe
handling practices of industrial scale Grignard reagents. Part 3 Analyses
of Grignard reagents: wet analyses of Grignard reagents; infrared and raman
spectroscopy; nuclear magnetic resonance analysis of Grignard reagents;
crystal structures of Grignard reagents. Part 4 Mechanisms and
structure-reactivity relationships: mechanism of Grignard reagent
formulation; mechanism of reactions in Grignard reagents;
structure-reactivity relationships; the composition of Grignard reagents in
solution - the Schlenk equilibrium and its effect on reactivity; effect of
tris(pyrazolyl)hydrobotato ligation. Part 5 General reactions of Grignard
reagents: nucleophilic substitution with electrophilic organic, main group
and transition metal species; nucleophilic addition to unconjugated C-C
multiple bond; nucleophilic addition of C-C multiple bonds - O, S, N, P;
nucleophilic addition to conjugated carbon-carbon bonds; nucleophilic
addition to conjugated carbon-heteroatom multiple bonds - O, S, N;
nucleophilic addition to organometallic vinylidene and allyl complexes.
Part 6 Special topics - applications and reactions of Grignard reagents:
the Barbier reaction; Grignard reagents as bases; Sn2 versus Sn21;
dihalide-derived di-Grignard reagents - preparation and reactions;
formation and reactions of substituted (2-butene-1,4-diyl)magnesium
complexes; spiroannulations using substituted (2-butene-1,4-diyl)magnesium
complexes; asymmetric synthesis using Grignard reagents; metal-catalyzed
reactions; the preparation of 1,1-bimetallics of magnesium and zinc;
alkynyl Grignard reagents and their uses; Grignard reagents and silanes;
Ziegler-Natta catalysis; organomagnesium compounds as polymerization
initiators.