Hematopoietic Stem Cell Transplantation for Neurologic Diseases (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity. - Reviews immunological mechanisms of HSCT and CNS autoimmunity - Identifies neurological diseases showing treatment efficacy with HSCT - Includes MS, myasthenia gravis, neuromyelitis optica, and more - Covers early and late side effects of HSCT

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 255
• Erscheinungstermin: 5. August 2024
• Englisch
• ISBN-13: 9780323902434
• Artikelnr.: 72251548

Inhaltsangabe

1. Introduction to HSCT for neurologic diseases
2. Modification of T and B cell-associated immuno-pathological mechanisms
in multiple sclerosis by disease modifying therapies: achievements and
opportunities
3. The hematopoietic niche and the autoreactive memory in autoimmune
disorders
4. The preclinical data and immunological rationale for hematopoietic stem
cell transplantation in autoimmunity
5. Immune cell reconstitution following autologous hematopoietic stem cell
transplantation in multiple sclerosis
6. Immune reconstitution in rheumatic disease patients after autologous
hematopoietic stem cell transplantation
7. The role of chemotherapy in hematopoietic stem cell transplantation HSCT
for autoimmune disorders: from lymphoablative to myeloablative conditioning
protocols
8. The HSCT procedure (I): mobilization, collection, manipulation and
cryopreservation of HSC
9. The HSCT procedure (II): conditioning, hemopoietic stem cell infusion,
supportive care and monitoring
10. Early and late complications of HSCT
11. Hematopoietic Stem Cell Transplantation for Multiple Sclerosis
12. Hematopoietic stem cell transplantation for neuromyelitis optica
spectrum disorder. Can immune tolerance be re-established?
13. Hematopoietic stem cell transplantation (HSCT) for chronic inflammatory
demyelinating polyradiculoneuropathy (CIDP): Is it CIDP?
14. HSCT for Stiff Person Syndrome and Myasthenia Gravis
15. Autologous hematopoietic stem cell transplantation for pediatric
autoimmune neurologic disorders
16. HSCT for systemic autoimmune diseases with neurologic involvement
17. Hematopoetic Stem Cell Therapy and Ex Vivo Gene Therapy for X-linked
Adrenoleukodystrophy
18. Economics of Hematopoietic Stem Cell Transplant in immune-mediated
neurologic autoimmune diseases
19. The EBMT-ADWP and the CIBMTR
20. Ongoing randomized clinical trials on HSCT in multiple sclerosis